AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway

被引:74
作者
Fehr, Desiree
Casanova, Carlo
Liverman, Amy
Blazkova, Hana
Orth, Kim
Dobbelaere, Dirk
Frey, Joachim
Burr, Sarah E.
机构
[1] Univ Bern, Inst Vet Bacteriol, Vetsuisse Fac, CH-3001 Bern, Switzerland
[2] Univ Bern, Div Mol Pathol, Vetsuisse Fac, CH-3001 Bern, Switzerland
[3] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX USA
来源
MICROBIOLOGY-SGM | 2006年 / 152卷
关键词
D O I
10.1099/mic.0.28889-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Aeromonas salmonicida subsp. salmonicida contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The aopP gene was detected in both typical and atypical A. salmonicida isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-kappa B) signalling pathways. AopP inhibits the NF-kappa B pathway downstream of I kappa B kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway.
引用
收藏
页码:2809 / 2818
页数:10
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