New farnesane-type sesquiterpenes, hedychiols A and B 8,9-diacetate, and inhibitors of degranulation in RBL-2H3 cells from the rhizome of Hedychium coronarium

被引：80

作者：

Morikawa, T ^{[1
]}

Matsuda, H ^{[1
]}

Sakamoto, Y ^{[1
]}

Ueda, K ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 08期

关键词：

hedychiol; Hedychium coronarium; degranulation inhibitor; hedychilactone A; coronarin D; Zingiberaceae;

D O I：

10.1248/cpb.50.1045

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two new farnesane-type sesquiterpenes, hedychiols A and B 8,9-diacetate, were isolated from the methanolic extract of the fresh rhizome of Hedychium coronarium KOEN. cultivated in Japan. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of isolated constituents on the release of beta-hexosaminidase from RBL-2H3 cells were examined, and hedychilactone A and coronarin D were found to show the inhibitory activity.

引用

收藏

页码：1045 / 1049

页数：5

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