Stem cells and lung cancer: future therapeutic targets?

被引：11

作者：

Alison, Malcolm R. ^{[1
]}

Lebrenne, Arielle C. ^{[1
]}

Islam, Shahriar ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Ctr Diabet & Metab Med, ICMS, London E1 2AT, England

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2009年 / 9卷 / 09期

关键词：

ALDH; bronchioalveolar duct junction (BADJ); CD133; drug resistance; EMT; lung cancer; SP; stem cells; ATYPICAL ADENOMATOUS HYPERPLASIA; SIDE POPULATION; GENE-EXPRESSION; ALDEHYDE DEHYDROGENASE; PROGENITOR CELLS; MOLECULAR PATHOGENESIS; SELF-RENEWAL; TUMOR-GROWTH; BASAL-CELLS; IDENTIFICATION;

D O I：

10.1517/14712590903103803

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In both the UK and USA more people die of lung cancer than any other type of cancer. Lung cancer's high mortality rate is also reflected on a global scale, with lung cancer accounting for more than 1 million deaths per year. In tissues with ordered structure such a lung epithelia, it is likely that the cancers have their origins in normal adult stem cells, and then the tumours themselves are maintained by a population of malignant stem cells - so-called cancer stem cells. This review examines both these postulates in animal models and in the clinical setting, noting that stem cell niches appear to foster tumour development, and that drug resistance can often be attributed to malignant cells with stem cell properties.

引用

页码：1127 / 1141

页数：15

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