High content analysis of the biocompatibility of nickel nanowires

被引：76

作者：

Byrne, Fiona ^{[1
,2
]}

Prina-Mello, Adriele ^{[1
,2
]}

Whelan, Aine ^{[1
,4
]}

Mohamed, Bashir M. ^{[3
]}

Davies, Anthony ^{[3
]}

Gun'ko, Yurii K. ^{[1
,4
]}

Coey, J. M. D. ^{[1
,2
]}

Volkov, Yuri ^{[1
,2
,3
]}

机构：

[1] Univ Dublin Trinity Coll, CRANN, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Sch Phys, Dublin 2, Ireland

[3] Univ Dublin Trinity Coll, Hlth Sci Ctr, Dept Clin Med, Dublin 8, Ireland

[4] Univ Dublin Trinity Coll, Sch Chem, Dublin 2, Ireland

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期

基金：

爱尔兰科学基金会;

关键词：

Magnetic nanowire; Nickel; Electrodeposition; Cytotoxicity; Biocompatibility; High content analysis; MAGNETIC NANOWIRES; CYTOTOXICITY; YIELD;

D O I：

10.1016/j.jmmm.2009.02.035

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Nickel nanowires, 20 mu m long and 200nm in diameter, were fabricated by electrodeposition into alumina templates, and characterised by superconducting quantum interference device (SQUID) magnetometer, X-ray diffraction and scanning electron microscopy. Biocompatibility studies of nickel nanowires with differentiated THP-1 cell line-derived macrophages were carried out. From a multiparametric assay, using high content analysis (HCA), the critical time points and concentrations of nickel nanowires on THP-1 cellular response were identified. The nanowires displayed little or no toxic effects on THP-1 cells over short incubation times (10h), and at low concentrations (<100 nanowires per cell). Our findings indicate the potential suitability of these wires for biological and clinical applications. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1341 / 1345

页数：5

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