Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection

被引：35

作者：

Akula, SM ^{[1
]}

Ford, PW ^{[1
]}

Whitman, AG ^{[1
]}

Hamden, KE ^{[1
]}

Shelton, JG ^{[1
]}

McCubrey, JA ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA

来源：

ONCOGENE | 2004年 / 23卷 / 30期

关键词：

HHV-8; KSHV; Raf; VEGF; HB-EGF;

D O I：

10.1038/sj.onc.1207643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human herpesvirus-8 (HHV-8/KSHV) is etiologically associated with Kaposi's sarcoma (KS) and other tumors. Constitutive activation of the mitogen-activated protein kinase ( MAPK) signaling pathway has been associated with a variety of tumors, including AIDS-related KS. The oncoprotein Raf is situated at a pivotal position in regulating the MAPK pathway. Hence, we analysed the effect of oncoprotein Raf on HHV-8 infectious entry into target cells. Here we report Raf expression to significantly enhance HHV-8 infection of target cells. These findings implicate a role for Raf not only in the infectious entry of HHV-8 but also in modulating KS pathogenesis.

引用

页码：5227 / 5241

页数：15

共 86 条

[1] Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases [J].

Ablashi, DV ;

Chatlynne, LG ;

Whitman, JE ;

Cesarman, E .

CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (03) :439-+

[2] DETECTION OF SEVERAL TYPES OF HUMAN PAPILLOMA VIRUSES IN AIDS-ASSOCIATED KAPOSIS-SARCOMA [J].

ADAMS, V ;

KEMPF, W ;

HASSAM, S ;

BRINER, J ;

SCHMID, M ;

MOOS, R ;

PFALTZ, M .

JOURNAL OF MEDICAL VIROLOGY, 1995, 46 (03) :189-193

[3] Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) infection of human fibroblast cells occurs through endocytosis [J].

Akula, SM ;

Naranatt, PP ;

Walia, NS ;

Wang, FZ ;

Fegley, B ;

Chandran, B .

JOURNAL OF VIROLOGY, 2003, 77 (14) :7978-7990

[4] Integrin α3β1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells [J].

Akula, SM ;

Pramod, NP ;

Wang, FZ ;

Chandran, B .

CELL, 2002, 108 (03) :407-419

[5] Human herpesvirus 8 interaction with target cells involves heparan sulfate [J].

Akula, SM ;

Wang, FZ ;

Vieira, J ;

Chandran, B .

VIROLOGY, 2001, 282 (02) :245-255

[6] Human herpesvirus 8 envelope-associated glycoprotein B interacts with heparan sulfate-like moieties [J].

Akula, SM ;

Pramod, NP ;

Wang, FZ ;

Chandran, B .

VIROLOGY, 2001, 284 (02) :235-249

[7] Vascular endothelial growth factor/vascular permeability factor in the pathogenesis of primary effusion lymphomas [J].

Aoki, Y ;

Tosato, G .

LEUKEMIA & LYMPHOMA, 2001, 41 (3-4) :229-+

[8] Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 [J].

Aoki, Y ;

Jones, KD ;

Tosato, G .

JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 2000, 9 (02) :137-145

[9] COMPARISON OF CONSTITUTIVE CYTOKINE RELEASE IN HIGH AND LOW HISTOLOGIC GRADE AIDS-RELATED KAPOSIS-SARCOMA CELL STRAINS AND IN SERA FROM HIV+/KS+ AND HIV+/KS+ PATIENTS [J].

BAILER, RT ;

LAZO, A ;

NGBAUTISTA, CL ;

HOUT, BL ;

NESS, GM ;

HEGTVEDT, AK ;

BLAKESLEE, JR ;

STEPHENS, RE ;

BRIERLEY, GP ;

MALLERY, SR .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1995, 15 (05) :473-483

[10] All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells [J].

Bairey, O ;

Boycov, O ;

Kaganovsky, E ;

Zimra, Y ;

Shaklai, M ;

Rabizadeh, E .

LEUKEMIA RESEARCH, 2004, 28 (03) :243-248

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