Downregulation of corticotropin-releasing factor mRNA, but not vasopressin mRNA, in the paraventricular hypothalamic nucleus of rats following nutritional stress

被引:38
作者
Hwang, BH
Guntz, JM
机构
[1] Department of Anatomy, Indiana Univ. School of Medicine, Indianapolis
关键词
food deprivation; CRF mRNA; vasopressin mRNA; hypothalamus;
D O I
10.1016/S0361-9230(97)80004-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stress can cause disturbance of homeostasis to result in illness, Stress can also induce various gene expression in different neuronal systems. For example, nutritional stress induced by acute food deprivation upregulates corticotropin-releasing factor (CRF) mRNA, whereas osmotic stress increases vasopressin (VP) mRNA, However, it is unknown if nutritional stress induced by chronic food deprivation has synergistic effects on CRF and VP mRNAs, We have used in situ hybridization in conjunction with quantitative autoradiography to demonstrate that nutritional stress induced by a 4-day food deprivation results in a body-weight loss with a significant decrease of CRF mRNAs, but not VP mRNAs in the paraventricular hypothalamic nucleus (PVN) of Sprague-Dawley rats. The present study has thus indicated that a chronic nutritional stress does not have synergistic effects on CRF and VP mRNAs, The decrease of CRF mRNAs is obviously related to the body-weight loss induced by food deprivation. This study thus supports a notion that the CRF, but not VP, neurons in the PVN play an important role in their neuroadaptation associated with body weight loss, Thus, it is conceivable that downregulated CRF neurons in the hypothalamus could be involved in pathogenesis of human eating disorder with severe weight loss, whereas upregulated CRF neurons could be associated with an opposite form of the eating disorder that causes obesity. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:509 / 514
页数:6
相关论文
共 47 条
[21]  
KOOB GF, 1991, STRESS NEUROBIOLOGY, P255
[22]   GALANIN-CONTAINING NEURONS IN THE SOLITARY NUCLEUS AND LOCUS-COERULEUS OF SPONTANEOUSLY HYPERTENSIVE RATS ARE ASSOCIATED WITH GENETIC-HYPERTENSION [J].
KUNKLER, PE ;
WANG, GM ;
HWANG, BH .
BRAIN RESEARCH, 1994, 651 (1-2) :349-352
[23]   LOWER GABA(A) RECEPTOR-BINDING IN THE AMYGDALA AND HYPOTHALAMUS OF SPONTANEOUSLY HYPERTENSIVE RATS [J].
KUNKLER, PE ;
HWANG, BH .
BRAIN RESEARCH BULLETIN, 1995, 36 (01) :57-61
[24]  
Laue L, 1991, Adv Pediatr, V38, P287
[25]   BRAIN NEUROPEPTIDE-Y - AN INTEGRATOR OF ENDOCRINE, METABOLIC AND BEHAVIORAL PROCESSES [J].
LEIBOWITZ, SF .
BRAIN RESEARCH BULLETIN, 1991, 27 (3-4) :333-337
[26]   NEUROCHEMICAL NEUROENDOCRINE SYSTEMS IN THE BRAIN CONTROLLING MACRONUTRIENT INTAKE AND METABOLISM [J].
LEIBOWITZ, SF .
TRENDS IN NEUROSCIENCES, 1992, 15 (12) :491-497
[27]   ORGANIZATION OF GALANIN-IMMUNOREACTIVE INPUTS TO THE PARAVENTRICULAR NUCLEUS WITH SPECIAL REFERENCE TO THEIR RELATIONSHIP TO CATECHOLAMINERGIC AFFERENTS [J].
LEVIN, MC ;
SAWCHENKO, PE ;
HOWE, PRC ;
BLOOM, SR ;
POLAK, JM .
JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 261 (04) :562-582
[28]   CORTICOTROPHIN-RELEASING FACTOR, VASOPRESSIN AND PRO-OPIOMELANOCORTIN MESSENGER-RNA RESPONSES TO STRESS AND OPIATES IN THE RAT [J].
LIGHTMAN, SL ;
YOUNG, WS .
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 403 :511-523
[29]   INCREASED EXPRESSION OF CORTICOTROPIN-RELEASING HORMONE AND VASOPRESSIN MESSENGER-RIBONUCLEIC-ACID (MESSENGER-RNA) IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS DURING REPEATED STRESS - ASSOCIATION WITH REDUCTION IN GLUCOCORTICOID RECEPTOR MESSENGER-RNA LEVELS [J].
MAKINO, S ;
SMITH, MA ;
GOLD, PW .
ENDOCRINOLOGY, 1995, 136 (08) :3299-3309
[30]   CORTICOTROPIN-RELEASING FACTOR ALONE, BUT NOT ARGININE-VASOPRESSIN ALONE, STIMULATES THE RELEASE OF ADRENOCORTICOTROPIN IN THE CONSCIOUS INTACT SHEEP [J].
MCFARLANE, A ;
COGHLAN, J ;
TRESHAM, J ;
WINTOUR, EM .
ENDOCRINOLOGY, 1995, 136 (05) :1821-1827