Survivin study: An update of "What is the next wave?"

被引：151

作者：

Li, Fengzhi

Ling, Xiang

机构：

[1] Roswell Pk Canc Inst, Dept Pharmacol & Therapeut, Grace Canc Drug Ctr, Buffalo, NY 14263 USA

[2] Tongji Univ, Sch Life Sci & Technol, Inst Canc, Shanghai 200092, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2006年 / 208卷 / 03期

关键词：

D O I：

10.1002/jcp.20634

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Studies on survivin over the past 2-3 years have shown that survivin possesses multiple subcellular localizations and is a multifunctional molecule involved in many aspects of cellular processes and/or behaviors. The subcellular localization and function of the survivin splice variants, however, have not yet been well elucidated. We have, therefore, provided additional observations on several survivin splice variants for further exploration. This review article will update the role of survivin, and its splice variants in the mitosis/cell cycle, apoptosis, tumorigenesis, chemoprevention, drug/radiation resistance, and cancer therapeutics.

引用

收藏

页码：476 / 486

页数：11

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