Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles

被引：61

作者：

Lewis, DFV ^{[1
]}

机构：

[1] Univ Surrey, Sch Biol Sci, Mol Toxicol Grp, Guildford GU2 5XH, Surrey, England

来源：

TOXICOLOGY | 2000年 / 144卷 / 1-3期

关键词：

cytochromes P450; drug metabolism; lipophilicity; QSARs;

D O I：

10.1016/S0300-483X(99)00207-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The factors with human P450 substrate selectivity are reviewed, together with extensive tabulation of quantitative relationships between structure and activity for many species of P450 substrates, inducers and inhibitors. In addition, the physicochemical characteristics (log P and pK(a) values) of heptic microsomal P450 substrates are collated, such that comparisons can be made on the grounds of compound lipophilicities. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：197 / 203

页数：7

共 37 条

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