Human beta-defensin-3: A promising antimicrobial peptide

被引:36
作者
Batoni, G. [1 ]
Maisetta, G. [1 ]
Esin, S. [1 ]
Campa, M. [1 ]
机构
[1] Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, I-56127 Pisa, Italy
关键词
antimicrobial peptides; human beta-defensin-3; drug resistant microorganisms; new antimicrobial drugs; peptide structure;
D O I
10.2174/138955706778560193
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The field of naturally occurring antimicrobial peptides is a research area rapidly expanding due to the high potential of such molecules as new antimicrobial drugs. In this regard, the human beta-defensin-3 is particularly attractive because of its strong antibacterial activity, relative salt-insensitiveness and low toxicity for host cells.
引用
收藏
页码:1063 / 1073
页数:11
相关论文
共 93 条
[81]   Effect of defensins on interleukin-8 synthesis in airway epithelial cells [J].
vanWetering, S ;
MannesseLazeroms, SPG ;
VanSterkenburg, MAJA ;
Daha, MR ;
Dijkman, JH ;
Hiemstra, PS .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1997, 272 (05) :L888-L896
[82]   A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence [J].
Vuong, C ;
Kocianova, S ;
Voyich, JM ;
Yao, YF ;
Fischer, ER ;
DeLeo, FR ;
Otto, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (52) :54881-54886
[83]   Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system [J].
Vuong, C ;
Voyich, JM ;
Fischer, ER ;
Braughton, KR ;
Whitney, AR ;
DeLeo, FR ;
Otto, M .
CELLULAR MICROBIOLOGY, 2004, 6 (03) :269-275
[84]   Inducible and constitutive β-defensins are differentially expressed in Crohn's disease and ulcerative colitis [J].
Wehkamp, J ;
Harder, J ;
Weichenthal, M ;
Mueller, O ;
Herrlinger, KR ;
Fellermann, K ;
Schroeder, JM ;
Stange, EF .
INFLAMMATORY BOWEL DISEASES, 2003, 9 (04) :215-223
[85]   IL-22 increases the innate immunity of tissues [J].
Wolk, K ;
Kunz, S ;
Witte, E ;
Friedrich, M ;
Asadullah, K ;
Sabat, R .
IMMUNITY, 2004, 21 (02) :241-254
[86]   Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3 [J].
Wu, ZB ;
Hoover, DM ;
Yang, D ;
Boulègue, C ;
Santamaria, F ;
Oppenheim, JJ ;
Lubkowski, J ;
Lu, WY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (15) :8880-8885
[87]   Identification of multiple novel epididymis-specific β-defensin isoforms in humans and mice [J].
Yamaguchi, Y ;
Nagase, T ;
Makita, R ;
Fukuhara, S ;
Tomita, T ;
Tominaga, T ;
Kurihara, H ;
Ouchi, Y .
JOURNAL OF IMMUNOLOGY, 2002, 169 (05) :2516-2523
[88]   Mammalian defensins in immunity: more than just microbicidal [J].
Yang, D ;
Biragyn, A ;
Kwak, LW ;
Oppenheim, JJ .
TRENDS IN IMMUNOLOGY, 2002, 23 (06) :291-296
[89]   β-defensins:: Linking innate and adaptive immunity through dendritic and T cell CCR6 [J].
Yang, D ;
Chertov, O ;
Bykovskaia, N ;
Chen, Q ;
Buffo, MJ ;
Shogan, J ;
Anderson, M ;
Schröder, JM ;
Wang, JM ;
Howard, OMZ ;
Oppenheim, JJ .
SCIENCE, 1999, 286 (5439) :525-528
[90]   Mechanisms of antimicrobial peptide action and resistance [J].
Yeaman, MR ;
Yount, NY .
PHARMACOLOGICAL REVIEWS, 2003, 55 (01) :27-55