Human beta-defensin-3: A promising antimicrobial peptide

被引:36
作者
Batoni, G. [1 ]
Maisetta, G. [1 ]
Esin, S. [1 ]
Campa, M. [1 ]
机构
[1] Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, I-56127 Pisa, Italy
关键词
antimicrobial peptides; human beta-defensin-3; drug resistant microorganisms; new antimicrobial drugs; peptide structure;
D O I
10.2174/138955706778560193
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The field of naturally occurring antimicrobial peptides is a research area rapidly expanding due to the high potential of such molecules as new antimicrobial drugs. In this regard, the human beta-defensin-3 is particularly attractive because of its strong antibacterial activity, relative salt-insensitiveness and low toxicity for host cells.
引用
收藏
页码:1063 / 1073
页数:11
相关论文
共 93 条
[61]  
Pristovsek P., 2001, Mini-Reviews in Medicinal Chemistry, V1, P409, DOI 10.2174/1389557013406729
[62]  
Quiñones-Mateu ME, 2003, AIDS, V17, pF39, DOI [10.1097/01.aids.0000096878.73209.4f, 10.1097/00002030-200311070-00001]
[63]   The JAK/STAT signaling pathway [J].
Rawlings, JS ;
Rosler, KM ;
Harrison, DA .
JOURNAL OF CELL SCIENCE, 2004, 117 (08) :1281-1283
[64]   Antimicrobial peptides: premises and promises [J].
Reddy, KVR ;
Yedery, RD ;
Aranha, C .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 24 (06) :536-547
[65]  
Ryley HC, 2001, REV MED MICROBIOL, V12, P177
[66]  
SAHL HG, 2005, J LEUKOCYTE BIOL, V77, P1
[67]   Burkholderia is highly resistant to human beta-defensin 3 [J].
Sahly, H ;
Schubert, S ;
Harder, J ;
Rautenberg, P ;
Ullmann, U ;
Schröder, J ;
Podschun, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (05) :1739-1741
[68]   Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis [J].
Saiman, L ;
Tabibi, S ;
Starner, TD ;
San Gabriel, P ;
Winokur, PL ;
Jia, HP ;
McCray, PB ;
Tack, BF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (10) :2838-2844
[69]   Correlated expression of human beta defensin-1, -2 and -3 mRNAs in gingival tissues of young children [J].
Saitoh, M ;
Abiko, Y ;
Shimabukuro, S ;
Kusano, K ;
Nishimura, M ;
Arakawa, T ;
Nakashima, K ;
Takuma, T ;
Kaku, T ;
Igarashi, S .
ARCHIVES OF ORAL BIOLOGY, 2004, 49 (10) :799-803
[70]   The solution structures of the human β-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus [J].
Schibli, DJ ;
Hunter, HN ;
Aseyev, V ;
Starner, TD ;
Wiencek, JM ;
McCray, PB ;
Tack, BF ;
Vogel, HJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) :8279-8289