Cross-Border Dissemination of Methicillin-Resistant Staphylococcus aureus, Euregio Meuse-Rhin Region

被引：41

作者：

Deurenberg, Ruud H. ^{[1
]}

Nulens, Eric ^{[2
]}

Valvatne, Havard

Sebastian, Silvie

Driessen, Christel

Craeghs, Jos ^{[3
]}

De Brauwer, Els ^{[4
]}

Heising, Bernhard ^{[5
]}

Kraat, Yvette J. ^{[6
]}

Riebe, Joachim ^{[7
]}

Stals, Frans S. ^{[8
]}

Trienekens, Thera A. ^{[9
]}

Scheres, Jacques

Friedrich, Alexander W. ^{[10
]}

van Tiel, Frank H.

Beisser, Patrick S.

Stobberingh, Ellen E.

机构：

[1] Univ Hosp Maastricht, Dept Med Microbiol, Maastricht Infect Ctr, NL-6202 AZ Maastricht, Netherlands

[2] Gen Hosp Sint Jan, Brugge, Belgium

[3] Gen Hosp Vesalius, Tongeren, Belgium

[4] Atrium Med Ctr, Heerlen, Netherlands

[5] Gen Hosp Duren, Duren, Germany

[6] Orbis Med & Care Ctr, Sittard, Netherlands

[7] Lab Aachen, Aachen, Germany

[8] Laurentius Hosp, Roermond, Netherlands

[9] VieCuri Med Ctr, Venlo, Netherlands

[10] Univ Munster, Munster, Germany

来源：

EMERGING INFECTIOUS DISEASES | 2009年 / 15卷 / 05期

关键词：

CASSETTE CHROMOSOME MEC; PANTON-VALENTINE LEUKOCIDIN; MULTIPLEX PCR; RAPID IDENTIFICATION; LEUCOCIDIN GENES; ACQUIRED STRAINS; EVOLUTION; VARIANTS; CLONES; LABORATORIES;

D O I：

10.3201/eid1505.071618

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Because the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) differs among the 3 countries forming the Euregio Meuse-Rhin (EMR) region (Belgium, Germany, and the Netherlands), cross-border healthcare requires information about the spread of MRSA in the EMR. We investigated the emergence, dissemination, and diversity of MRSA clones in the EMIR by using several typing methods. MRSA associated with clonal complexes 5, 8, 30, and 45 was disseminated throughout the EMR. Dutch isolates, mainly associated with sequence types (ST) ST5-MRSA-II, ST5-MRSA-IV, ST8-MRSA-IV, and ST45-MSRA-IV had a more diverse genetic background than the isolates from Belgium and Germany, associated with ST45-MRSA-IV and ST5-MRSA-II, respectively. MRSA associated with pigs (ST398-MRSA-IV/V) was found in the Dutch area of the EMR. Five percent of the MRSA isolates harbored Panton-Valentine leukocidin and were classified as community-associated MRSA associated with ST1, 8, 30, 80, and 89.

引用

页码：727 / 734

页数：8

共 39 条

[31] Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006 [J].

Tristan, Anne ;

Bes, Michele ;

Meugnier, Helene ;

Lina, Gerard ;

Bozdogan, Bulent ;

Courvalin, Patrice ;

Reverdy, Marie-Elisabeth ;

Enright, Mark C. ;

Vandenesch, Francois ;

Etienne, Jerome .

EMERGING INFECTIOUS DISEASES, 2007, 13 (04) :594-600

[32] Increase in a Dutch hospital of methicillin-resistant Staphylococcus aureus related to animal farming [J].

van Rijen, Miranda Maria Lucia ;

Van Keulen, Peter H. ;

Kluytmans, Jan A. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (02) :261-263

[33] Emergence of virulent methicillin-resistant Staphylococcus aureus strains carrying Panton-Valentine leucocidin genes in the Netherlands [J].

Wannet, WJB ;

Spalburg, E ;

Heck, MEOC ;

Pluister, GN ;

Tiemersma, E ;

Willems, RJL ;

Huijsdens, XW ;

de Neeling, AJ ;

Etienne, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (07) :3341-3345

[34] The role of nasal carriage in Staphylococcus aureus infections [J].

Wertheim, HFL ;

Melles, DC ;

Vos, MC ;

van Leeuwen, W ;

van Belkum, A ;

Verbrugh, HA ;

Nouwen, JL .

LANCET INFECTIOUS DISEASES, 2005, 5 (12) :751-762

[35] Evidence for in-vivo transfer of mecA DNA between strains of Staphylococcus aureus [J].

Wielders, CLC ;

Vriens, MR ;

Brisse, S ;

de Graaf-Miltenburg, LAM ;

Troelstra, A ;

Fleer, A ;

Schmitz, FJ ;

Verhoef, J ;

Fluit, AC .

LANCET, 2001, 357 (9269) :1674-1675

[36] Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe [J].

Witte, Wolfgang ;

Strommenger, Birgit ;

Stanek, Christian ;

Cuny, Christiane .

EMERGING INFECTIOUS DISEASES, 2007, 13 (02) :255-258

[37] Cross-border cooperation in Europe: What are Euregios? [J].

Wolf, U. ;

Hollederer, A. ;

Brand, H. .

GESUNDHEITSWESEN, 2006, 68 (11) :667-673

[38] Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians:: an international study [J].

Wulf, M. W. H. ;

Sorum, M. ;

van Nes, A. ;

Skov, R. ;

Melchers, W. J. G. ;

Klaassen, C. H. W. ;

Voss, A. .

CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 (01) :29-34

[39] Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus [J].

Zhang, KY ;

McClure, JA ;

Elsayed, S ;

Louie, T ;

Conly, JM .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (10) :5026-5033

← 1 2 3 4 →