Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach

被引：15

作者：

Song, Min ^{[1
]}

Zhang, Jian ^{[2
]}

Chan, Ging ^{[1
]}

Hou, Ying ^{[1
]}

Chen, Xiu-Ping ^{[1
]}

Zhang, Xiao-Qi ^{[2
]}

Ye, Wen-Cai ^{[2
]}

Zhang, Qing-Wen ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[2] Jinan Univ, Coll Pharm, Guangdong Prov Engn Res Ctr Modernizat TCM, Guangzhou 510632, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 12期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

CYTOTOXIC LIMONOIDS;

D O I：

10.1021/acs.jnatprod.9b01151

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Nine new limonoids, meliazedarines A-I (1-9), seven known analogues (10-16), and five known triterpenoids (17-21) were isolated from the fruits of Melia azedarach. Their structures were determined by analysis of 1D and 2D NMR, HRESIMS, X-ray diffraction, and electronic circular dichroism (ECD) data. Compound 7 showed significant cytotoxicity against the HCT116 cell line with IC50 values of 0.3 +/- 0.1 mu M.

引用

页码：3502 / 3510

页数：9

共 28 条

[1]

SpecDis: Quantifying the Comparison of Calculated and Experimental Electronic Circular Dichroism Spectra [J].

Bruhn, Torsten ;

Schaumloeffel, Anu ;

Hemberger, Yasmin ;

Bringmann, Gerhard .

CHIRALITY, 2013, 25 (04) :243-249

[2]

Ding Li, 2013, Cancer Biology Medicine, V10, P16, DOI 10.7497/j.issn.2095-3941.2013.01.003

[3]

MELIACINS (LIMONOIDS) . NIMBOLIN A AND B, 2 NEW MELIACIN CINNAMATES FROM AZADIRACHTA INDICA L AND MELIA AZEDARACH L [J].

EKONG, DEU ;

FAKUNLE, CO ;

FASINA, AK ;

OKOGUN, JI .

JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1969, (20) :1166-&

[4]

Frisch M. J., 2009, Gaussian 09, Revision D.01

[5]

USE OF MTT COLORIMETRIC ASSAY TO MEASURE CELL ACTIVATION [J].

GERLIER, D ;

THOMASSET, N .

JOURNAL OF IMMUNOLOGICAL METHODS, 1986, 94 (1-2) :57-63

[6]

Isolation of a new tetranortriterpenoid from the uncrushed green leaves of Azadirachta indica [J].

Govindachari, TR ;

Malathi, R ;

Gopalakrishnan, G ;

Suresh, G ;

Rajan, SS .

PHYTOCHEMISTRY, 1999, 52 (06) :1117-1119

[7]

Limonoids from the fruits of Melia toosendan [J].

Hu, Jin-Feng ;

Fan, Hui ;

Wang, Li-Jun ;

Wu, Shi-Biao ;

Zhao, Yun .

PHYTOCHEMISTRY LETTERS, 2011, 4 (03) :292-297

[8]

Cablinosides A and B, Two Glycosidic Phenylacetic Acid Derivatives from the Leaves of Pogostemon cablin [J].

Huang, Xiao-Jun ;

Li, Ping ;

Yin, Zhi-Qi ;

Lu, Jin-Jian ;

Lin, Li-Gen ;

Wang, Ying ;

Ye, Wen-Cai ;

Zhang, Qing-Wen .

CHEMISTRY & BIODIVERSITY, 2019, 16 (05)

[9]

NEW TETRANORTRITERPENOIDS FROM MELIA-AZEDARACH LINN (MELIACEAE) [J].

KRAUS, W ;

BOKEL, M .

CHEMISCHE BERICHTE-RECUEIL, 1981, 114 (01) :267-275

[10]

Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata [J].

Liu, Zhi-Wen ;

Zhang, Jian ;

Li, Song-Tao ;

Liu, Ming-Qun ;

Huang, Xiao-Jun ;

Ao, Yun-Lin ;

Fan, Chun-Lin ;

Zhang, Dong-Mei ;

Zhang, Qing-Wen ;

Ye, Wen-Cai ;

Zhang, Xiao-Qi .

JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (17) :10613-10618

← 1 2 3 →