Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata

被引：35

作者：

Liu, Zhi-Wen ^{[1
,2
]}

Zhang, Jian ^{[1
,2
,3
,4
]}

Li, Song-Tao ^{[1
,2
]}

Liu, Ming-Qun ^{[1
,2
]}

Huang, Xiao-Jun ^{[1
,2
]}

Ao, Yun-Lin ^{[1
,2
]}

Fan, Chun-Lin ^{[1
,2
]}

Zhang, Dong-Mei ^{[1
,2
]}

Zhang, Qing-Wen ^{[3
,4
]}

Ye, Wen-Cai ^{[1
,2
]}

Zhang, Xiao-Qi ^{[1
,2
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[3] Univ Macau, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China

[4] Univ Macau, Inst Chinese Med Sci, Taipa, Macao, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 17期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

IBOGA-TYPE ALKALOIDS; TABERNAEMONTANA-DIVARICATA; OFFICINALIS; HAINANENSIS; PRECURSOR; ROOT;

D O I：

10.1021/acs.joc.8b01371

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C-C and C-N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound 1 exhibited significant cytotoxicity against four cancer cells.

引用

页码：10613 / 10618

页数：6

共 21 条

[1]

ALKALOIDS FROM LEAVES AND ROOT BARK OF ERVATAMIA-HIRTA [J].