Listening in on bacteria: Acyl-homoserine lactone signalling

被引:788
作者
Fuqua, C
Greenberg, EP [1 ]
机构
[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1038/nrm907
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Bacterial cell-to-cell signalling has emerged as a new area in microbiology. Individual bacterial cells communicate with each other and co-ordinate group activities. Although a lot of detail is known about the mechanisms of a few well-characterized bacterial communication systems, other systems have been discovered only recently. Bacterial intercellular communication has become a target for the development of new anti-virulence drugs.
引用
收藏
页码:685 / 695
页数:11
相关论文
共 115 条
[91]   Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections [J].
Rumbaugh, KP ;
Griswold, JA ;
Iglewski, BH ;
Hamood, AN .
INFECTION AND IMMUNITY, 1999, 67 (11) :5854-5862
[92]   Generation of cell-to-cell signals in quorum sensing: Acyl homoserine lactone synthase activity of a purified Vibrio fescheri LuxI protein [J].
Schaefer, AL ;
Val, DL ;
Hanzelka, BL ;
Cronan, JE ;
Greenberg, EP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9505-9509
[93]   The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule [J].
Schauder, S ;
Shokat, K ;
Surette, MG ;
Bassler, BL .
MOLECULAR MICROBIOLOGY, 2001, 41 (02) :463-476
[94]   Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms [J].
Singh, PK ;
Schaefer, AL ;
Parsek, MR ;
Moninger, TO ;
Welsh, MJ ;
Greenberg, EP .
NATURE, 2000, 407 (6805) :762-764
[95]   Quorum sensing in Vibrio fischeri: Essential elements for activation of the luminescence genes [J].
Stevens, AM ;
Greenberg, EP .
JOURNAL OF BACTERIOLOGY, 1997, 179 (02) :557-562
[96]  
Stevens AM, 1999, CELL-CELL SIGNALING IN BACTERIA, P231
[97]   Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi:: A new family of genes responsible for autoinducer production [J].
Surette, MG ;
Miller, MB ;
Bassler, BL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1639-1644
[98]   Quorum sensing in Escherichia coli and Salmonella typhimurium [J].
Surette, MG ;
Bassler, BL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :7046-7050
[99]   Inhibition of the Agrobacterium tumefaciens TraR quorum-sensing regulator -: Interactions with the tram anti-activator [J].
Swiderska, A ;
Berndtson, AK ;
Cha, MR ;
Li, L ;
Beaudoin, GMJ ;
Zhu, J ;
Fuqua, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) :49449-49458
[100]   Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria [J].
Teplitski, M ;
Robinson, JB ;
Bauer, WD .
MOLECULAR PLANT-MICROBE INTERACTIONS, 2000, 13 (06) :637-648