Listening in on bacteria: Acyl-homoserine lactone signalling

被引:788
作者
Fuqua, C
Greenberg, EP [1 ]
机构
[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1038/nrm907
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Bacterial cell-to-cell signalling has emerged as a new area in microbiology. Individual bacterial cells communicate with each other and co-ordinate group activities. Although a lot of detail is known about the mechanisms of a few well-characterized bacterial communication systems, other systems have been discovered only recently. Bacterial intercellular communication has become a target for the development of new anti-virulence drugs.
引用
收藏
页码:685 / 695
页数:11
相关论文
共 115 条
[41]   The evolution of bacterial LuxI and LuxR quorum sensing regulators [J].
Gray, KM ;
Garey, JR .
MICROBIOLOGY-SGM, 2001, 147 :2379-2387
[42]  
Greenberg EP, 1999, SYMP SOC GEN MICROBI, V57, P71
[43]   INDUCTION OF LUCIFERASE SYNTHESIS IN BENECKEA-HARVEYI BY OTHER MARINE-BACTERIA [J].
GREENBERG, EP ;
HASTINGS, JW ;
ULITZUR, S .
ARCHIVES OF MICROBIOLOGY, 1979, 120 (02) :87-91
[44]   Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein [J].
Hanzelka, BL ;
Parsek, MR ;
Val, DL ;
Dunlap, PV ;
Cronan, JE ;
Greenberg, EP .
JOURNAL OF BACTERIOLOGY, 1999, 181 (18) :5766-5770
[45]   Mutational analysis of the Vibrio fischeri LuxI polypeptide: Critical regions of an autoinducer synthase [J].
Hanzelka, BL ;
Stevens, AM ;
Parsek, MR ;
Crone, TJ ;
Greenberg, EP .
JOURNAL OF BACTERIOLOGY, 1997, 179 (15) :4882-4887
[46]   EVIDENCE THAT THE N-TERMINAL REGION OF THE VIBRIO-FISCHERI LUXR PROTEIN CONSTITUTES AN AUTOINDUCER-BINDING DOMAIN [J].
HANZELKA, BL ;
GREENBERG, EP .
JOURNAL OF BACTERIOLOGY, 1995, 177 (03) :815-817
[47]  
HENIKOFF S, 1990, METHOD ENZYMOL, V183, P111
[48]   Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound [J].
Hentzer, M ;
Riedel, K ;
Rasmussen, TB ;
Heydorn, A ;
Andersen, JB ;
Parsek, MR ;
Rice, SA ;
Eberl, L ;
Molin, S ;
Hoiby, N ;
Kjelleberg, S ;
Givskov, M .
MICROBIOLOGY-SGM, 2002, 148 :87-102
[49]   Statistical analysis of Pseudomonas aeruginosa biofilm development:: Impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression [J].
Heydorn, A ;
Ersboll, B ;
Kato, J ;
Hentzer, M ;
Parsek, MR ;
Tolker-Nielsen, T ;
Givskov, M ;
Molin, S .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2002, 68 (04) :2008-2017
[50]  
Horinouchi S, 1999, CELL-CELL SIGNALING IN BACTERIA, P193