Reactivity switching on solid support:: solid-phase synthesis of tertiary amines by reduction of tertiary amides with LiAIH4

被引：16

作者：

Akamatsu, H ^{[1
]}

Kusumoto, S ^{[1
]}

Fukase, K ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Chem, Toyonaka, Osaka 5600043, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(02)02202-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactivity of LiAlH4 was controlled by using solid-phase reaction conditions. Tertiary amides bound to gel-type polystyrene support were reduced with LiAlH4 to give tertiary amines with satisfactory purity, whereas the reduction of similar tertiary amides in solution gave secondary amines as main products. Solid-phase synthesis of tertiary amine libraries was achieved by using this method. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8867 / 8869

页数：3

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