Interaction of chlorpromazine with phospholipid membranes: A monolayer and a microelectrophoresis approach

被引：16

作者：

Bennouna, M

FerreiraMarques, J

Banerjee, S

Caspers, J

Ruysschaert, JM

机构：

[1] FREE UNIV BRUSSELS,CHIM PHYS MACROMOL INTERFACES LAB,B-1050 BRUSSELS,BELGIUM

[2] UNIV ABDELMALEK ESAADI,FAC SCI TETOUAN,TETOUAN,MOROCCO

来源：

LANGMUIR | 1997年 / 13卷 / 24期

关键词：

D O I：

10.1021/la970203+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chlorpromazine penetration into the lipid core of the membrane was demonstrated through measurements on lipid monolayers (surface pressure and surface potential). The surface pressure measurements allow us to calculate the intrinsic binding constant (partition coefficient) for the lipid-Chlorpromazine interaction. This latter value is in correct agreement with the obtained results by electrophoretic mobilities measurements on liposomes.

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收藏

页码：6533 / 6539

页数：7

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