Rel/NF-kappa B and I kappa B proteins: an overview

被引：334

作者：

May, MJ ^{[1
]}

Ghosh, S ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT BIOCHEM & MOL BIOPHYS,NEW HAVEN,CT 06520

来源：

SEMINARS IN CANCER BIOLOGY | 1997年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

I kappa B; NF-kappa B; Rel proteins; transcription factors; DNA-binding proteins;

D O I：

10.1006/scbi.1997.0057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rel/NF-kappa B proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the I kappa B proteins. In this review, we will familiarize the reader with the known Rel/NF-kappa B and I kappa B molecules, and will discuss the types of interactions that occur between these proteins to regulate their function. In addition, we will describe what is known about the structure of Rel/NF-kappa B transcription complexes on DNA. Lastly, we will discuss the wide variety of biological stimuli and conditions which activate NF-kappa B and the genes whose expression are regulated by this family of transcription factors. (C) 1997 Academic Press Ltd.

引用

页码：63 / 73

页数：11

共 114 条

[1] A 65-KD SUBUNIT OF ACTIVE NF-KAPPA-B IS REQUIRED FOR INHIBITION OF NF-KAPPA-B BY I-KAPPA-B [J].

BAEUERLE, PA ;

BALTIMORE, D .

GENES & DEVELOPMENT, 1989, 3 (11) :1689-1698

[2] I-KAPPA-B - A SPECIFIC INHIBITOR OF THE NF-KAPPA-B TRANSCRIPTION FACTOR [J].

BAEUERLE, PA ;

BALTIMORE, D .

SCIENCE, 1988, 242 (4878) :540-546

[3] The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization [J].

Beauparlant, P ;

Lin, RT ;

Hiscott, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (18) :10690-10696

[4]

BEG AA, 1992, GENE DEV, V6, P2664

[5] I-KAPPA-B INTERACTS WITH THE NUCLEAR-LOCALIZATION SEQUENCES OF THE SUBUNITS OF NF-KAPPA-B - A MECHANISM FOR CYTOPLASMIC RETENTION [J].

BEG, AA ;

RUBEN, SM ;

SCHEINMAN, RI ;

HASKILL, S ;

ROSEN, CA ;

BALDWIN, AS .

GENES & DEVELOPMENT, 1992, 6 (10) :1899-1913

[6]

Betts JC, 1996, MOL CELL BIOL, V16, P6363

[7] MUTATIONAL ANALYSIS OF THE TRANSCRIPTION ACTIVATION DOMAIN OF RELA - IDENTIFICATION OF A HIGHLY SYNERGISTIC MINIMAL ACIDIC ACTIVATION MODULE [J].

BLAIR, WS ;

BOGERD, HP ;

MADORE, SJ ;

CULLEN, BR .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (11) :7226-7234

[8] THE ONCOPROTEIN BCL-3 DIRECTLY TRANSACTIVATES THROUGH KAPPA-B MOTIFS VIA ASSOCIATION WITH DNA-BINDING P50B HOMODIMERS [J].

BOURS, V ;

FRANZOSO, G ;

AZARENKO, V ;

PARK, S ;

KANNO, T ;

BROWN, K ;

SIEBENLIST, U .

CELL, 1993, 72 (05) :729-739

[9] SIMILARITY BETWEEN CELL-CYCLE GENES OF BUDDING YEAST AND FISSION YEAST AND THE NOTCH GENE OF DROSOPHILA [J].

BREEDEN, L ;

NASMYTH, K .

NATURE, 1987, 329 (6140) :651-654

[10] MUTATIONAL ANALYSIS OF THE P50-SUBUNIT OF NF-KAPPA-B AND INHIBITION OF NF-KAPPA-B ACTIVITY BY TRANSDOMINANT P50 MUTANTS [J].

BRESSLER, P ;

BROWN, K ;

TIMMER, W ;

BOURS, V ;

SIEBENLIST, U ;

FAUCI, AS .

JOURNAL OF VIROLOGY, 1993, 67 (01) :288-293

← 1 2 3 4 5 6 7 8 9 10 →