Rel/NF-kappa B and I kappa B proteins: an overview

被引：334

作者：

May, MJ ^{[1
]}

Ghosh, S ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT BIOCHEM & MOL BIOPHYS,NEW HAVEN,CT 06520

来源：

SEMINARS IN CANCER BIOLOGY | 1997年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

I kappa B; NF-kappa B; Rel proteins; transcription factors; DNA-binding proteins;

D O I：

10.1006/scbi.1997.0057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rel/NF-kappa B proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the I kappa B proteins. In this review, we will familiarize the reader with the known Rel/NF-kappa B and I kappa B molecules, and will discuss the types of interactions that occur between these proteins to regulate their function. In addition, we will describe what is known about the structure of Rel/NF-kappa B transcription complexes on DNA. Lastly, we will discuss the wide variety of biological stimuli and conditions which activate NF-kappa B and the genes whose expression are regulated by this family of transcription factors. (C) 1997 Academic Press Ltd.

引用

页码：63 / 73

页数：11

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