Rel/NF-kappa B and I kappa B proteins: an overview

被引：334

作者：

May, MJ ^{[1
]}

Ghosh, S ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT BIOCHEM & MOL BIOPHYS,NEW HAVEN,CT 06520

来源：

SEMINARS IN CANCER BIOLOGY | 1997年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

I kappa B; NF-kappa B; Rel proteins; transcription factors; DNA-binding proteins;

D O I：

10.1006/scbi.1997.0057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rel/NF-kappa B proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the I kappa B proteins. In this review, we will familiarize the reader with the known Rel/NF-kappa B and I kappa B molecules, and will discuss the types of interactions that occur between these proteins to regulate their function. In addition, we will describe what is known about the structure of Rel/NF-kappa B transcription complexes on DNA. Lastly, we will discuss the wide variety of biological stimuli and conditions which activate NF-kappa B and the genes whose expression are regulated by this family of transcription factors. (C) 1997 Academic Press Ltd.

引用

页码：63 / 73

页数：11

共 114 条

[61]

Lin L, 1996, MOL CELL BIOL, V16, P2248

[62] DIFFERENTIAL TRANSCRIPTIONAL ACTIVATION IN-VITRO BY NF-KAPPA-B/REL PROTEINS [J].

LIN, RT ;

GEWERT, D ;

HISCOTT, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (07) :3123-3131

[63] SEQUENTIAL INDUCTION OF NF-KAPPA-B/REL FAMILY PROTEINS DURING B-CELL TERMINAL DIFFERENTIATION [J].

LIOU, HC ;

SHA, WC ;

SCOTT, ML ;

BALTIMORE, D .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (08) :5349-5359

[64] INHIBITION OF TRANSCRIPTION FACTORS BELONGING TO THE REL/NF-KAPPA-B FAMILY BY A TRANSDOMINANT NEGATIVE MUTANT [J].

LOGEAT, F ;

ISRAEL, N ;

TEN, R ;

BLANK, V ;

LEBAIL, O ;

KOURILSKY, P ;

ISRAEL, A .

EMBO JOURNAL, 1991, 10 (07) :1827-1832

[65] TRANSCRIPTION FACTORS NF-IL6 AND NF-KAPPA-B SYNERGISTICALLY ACTIVATE TRANSCRIPTION OF THE INFLAMMATORY CYTOKINES, INTERLEUKIN-6 AND INTERLEUKIN-8 [J].

MATSUSAKA, T ;

FUJIKAWA, K ;

NISHIO, Y ;

MUKAIDA, N ;

MATSUSHIMA, K ;

KISHIMOTO, T ;

AKIRA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10193-10197

[66] P105 AND P98 PRECURSOR PROTEINS PLAY AN ACTIVE-ROLE IN NF-KAPPA-B-MEDIATED SIGNAL TRANSDUCTION [J].

MERCURIO, F ;

DIDONATO, JA ;

ROSETTE, C ;

KARIN, M .

GENES & DEVELOPMENT, 1993, 7 (04) :705-718

[67] ENHANCED I-KAPPA-B-ALPHA DEGRADATION IS RESPONSIBLE FOR CONSTITUTIVE NF-KAPPA-B ACTIVITY IN MATURE MURINE B-CELL LINES [J].

MIYAMOTO, S ;

CHIAO, PJ ;

VERMA, IM .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3276-3282

[68] NF-KAPPA-B - A FAMILY OF INDUCIBLE AND DIFFERENTIALLY EXPRESSED ENHANCER-BINDING PROTEINS IN HUMAN T-CELLS [J].

MOLITOR, JA ;

WALKER, WH ;

DOERRE, S ;

BALLARD, DW ;

GREENE, WC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :10028-10032

[69] A PROTEIN KINASE-A RECOGNITION SEQUENCE IS STRUCTURALLY LINKED TO TRANSFORMATION BY P59V-REL AND CYTOPLASMIC RETENTION OF P68C-REL [J].

MOSIALOS, G ;

HAMER, P ;

CAPOBIANCO, AJ ;

LAURSEN, RA ;

GILMORE, TD .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (12) :5867-5877

[70] STRUCTURE OF THE NF-KAPPA-B P50 HOMODIMER BOUND TO DNA [J].

MULLER, CW ;

REY, FA ;

SODEOKA, M ;

VERDINE, GL ;

HARRISON, SC .

NATURE, 1995, 373 (6512) :311-317

← 2 3 4 5 6 7 8 9 10 11 →