Recent advances in sample preparation techniques to overcome difficulties encountered during quantitative analysis of small molecules from biofluids using LC-MS/MS

被引：202

作者：

Bylda, Caroline ^{[1
,2
]}

Thiele, Roland ^{[1
]}

Kobold, Uwe ^{[1
]}

Volmer, Dietrich A. ^{[2
]}

机构：

[1] Roche Diagnost GmbH, Penzberg, Germany

[2] Univ Saarland, Inst Bioanalyt Chem, D-66123 Saarbrucken, Germany

来源：

ANALYST | 2014年 / 139卷 / 10期

关键词：

SOLID-PHASE EXTRACTION; TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; WALLED CARBON NANOTUBES; SPIN COLUMN EXTRACTION; ASSISTED LIQUID/LIQUID EXTRACTION; RESTRICTED-ACCESS MATERIALS; LABELED INTERNAL STANDARD; HUMAN-PLASMA; IMPRINTED POLYMER;

D O I：

10.1039/c4an00094c

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

Liquid chromatography-mass spectrometry analysis of small molecules from biofluids requires sensitive and robust assays. Because of the very complex nature of many biological samples, efficient sample preparation protocols to remove unwanted components and to selectively extract the compounds of interest are an essential part of almost every bioanalytical workflow. This review describes the most common problems encountered during sample preparation, ways to optimize established sample preparation techniques and important recent developments to reduce or eliminate major interferents from biofluids.

引用

页码：2265 / 2276

页数：12

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