RNA silencing: small RNAs as ubiquitous regulators of gene expression

被引:101
作者
Voinnet, O
机构
[1] John Innes Inst, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England
[2] IBMP, F-67084 Strasbourg, France
关键词
D O I
10.1016/S1369-5266(02)00291-1
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
'RNA silencing' is the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by RNA. Initially identified as an immune system that is targeted against transposons and viruses, RNA silencing is emerging as a fundamental regulatory process that is likely to affect many layers of endogenous gene expression in most, if not all, eukaryotes.
引用
收藏
页码:444 / 451
页数:8
相关论文
共 62 条
  • [1] A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants
    Anandalakshmi, R
    Marathe, R
    Ge, X
    Herr, JM
    Mau, C
    Mallory, A
    Pruss, G
    Bowman, L
    Vance, VB
    [J]. SCIENCE, 2000, 290 (5489) : 142 - 144
  • [2] A viral suppressor of gene silencing in plants
    Anandalakshmi, R
    Pruss, GJ
    Ge, X
    Marathe, R
    Mallory, AC
    Smith, TH
    Vance, VB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) : 13079 - 13084
  • [3] A branched pathway for transgene-induced RNA silencing in plants
    Béclin, C
    Boutet, S
    Waterhouse, P
    Vaucheret, H
    [J]. CURRENT BIOLOGY, 2002, 12 (08) : 684 - 688
  • [4] Role for a bidentate ribonuclease in the initiation step of RNA interference
    Bernstein, E
    Caudy, AA
    Hammond, SM
    Hannon, GJ
    [J]. NATURE, 2001, 409 (6818) : 363 - 366
  • [5] RETRACTED: Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana (Retracted article. See vol. 34, pg. 2595, 2015)
    Brigneti, G
    Voinnet, O
    Li, WX
    Ji, LH
    Ding, SW
    Baulcombe, DC
    [J]. EMBO JOURNAL, 1998, 17 (22) : 6739 - 6746
  • [6] Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain
    Cerutti, L
    Mian, N
    Bateman, A
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (10) : 481 - 482
  • [7] MUTATIONS THAT LEAD TO REITERATIONS IN THE CELL LINEAGES OF C-ELEGANS
    CHALFIE, M
    HORVITZ, HR
    SULSTON, JE
    [J]. CELL, 1981, 24 (01) : 59 - 69
  • [8] An RNA-Dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
    Dalmay, T
    Hamilton, A
    Rudd, S
    Angell, S
    Baulcombe, DC
    [J]. CELL, 2000, 101 (05) : 543 - 553
  • [9] RNA interference is mediated by 21-and 22-nucleotide RNAs
    Elbashir, SM
    Lendeckel, W
    Tuschl, T
    [J]. GENES & DEVELOPMENT, 2001, 15 (02) : 188 - 200
  • [10] Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    Elbashir, SM
    Martinez, J
    Patkaniowska, A
    Lendeckel, W
    Tuschl, T
    [J]. EMBO JOURNAL, 2001, 20 (23) : 6877 - 6888