RNA silencing: small RNAs as ubiquitous regulators of gene expression

被引：101

作者：

Voinnet, O

机构：

[1] John Innes Inst, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England

[2] IBMP, F-67084 Strasbourg, France

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2002年 / 5卷 / 05期

关键词：

D O I：

10.1016/S1369-5266(02)00291-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

'RNA silencing' is the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by RNA. Initially identified as an immune system that is targeted against transposons and viruses, RNA silencing is emerging as a fundamental regulatory process that is likely to affect many layers of endogenous gene expression in most, if not all, eukaryotes.

引用

页码：444 / 451

页数：8

共 62 条

[21] A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
Hutvágner, G
McLachlan, J
Pasquinelli, AE
Bálint, É
Tuschl, T
Zamore, PD
[J]. SCIENCE, 2001, 293 (5531) : 834 - 838
[22] Jacobsen SE, 1999, DEVELOPMENT, V126, P5231
[23] Taming of transposable elements by homology-dependent gene silencing
Jensen, S
Gassama, MP
Heidmann, T
[J]. NATURE GENETICS, 1999, 21 (02) : 209 - 212
[24] A counterdefensive strategy of plant viruses: Suppression of posttranscriptional gene silencing
Kasschau, KD
Carrington, JC
[J]. CELL, 1998, 95 (04) : 461 - 470
[25] Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C-elegans
Ketting, RF
Fischer, SEJ
Bernstein, E
Sijen, T
Hannon, GJ
Plasterk, RHA
[J]. GENES & DEVELOPMENT, 2001, 15 (20) : 2654 - 2659
[26] mut-7 of C-elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
Ketting, RF
Haverkamp, THA
van Luenen, HGAM
Plasterk, RHA
[J]. CELL, 1999, 99 (02) : 133 - 141
[27] Identification of novel genes coding for small expressed RNAs
Lagos-Quintana, M
Rauhut, R
Lendeckel, W
Tuschl, T
[J]. SCIENCE, 2001, 294 (5543) : 853 - 858
[28] Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
Lai, EC
[J]. NATURE GENETICS, 2002, 30 (04) : 363 - 364
[29] An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
Lau, NC
Lim, LP
Weinstein, EG
Bartel, DP
[J]. SCIENCE, 2001, 294 (5543) : 858 - 862
[30] An extensive class of small RNAs in Caenorhabditis elegans
Lee, RC
Ambros, V
[J]. SCIENCE, 2001, 294 (5543) : 862 - 864

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