Nanoporous Hydrogen Bonded Polymeric Microparticles: Facile and Economic Production of Cross Presentation Promoting Vaccine Carriers

被引：50

作者：

Dierendonck, Marijke ^{[1
]}

Fierens, Kaat ^{[2
,3
]}

De Rycke, Riet ^{[2
]}

Lybaert, Lien ^{[1
]}

Maji, Samarendra ^{[4
]}

Zhang, Zhiyue ^{[1
,4
]}

Zhang, Qilu

Hoogenboom, Richard ^{[4
]}

Lambrecht, Bart N. ^{[2
,3
]}

Grooten, Johan ^{[5
]}

Remon, Jean Paul ^{[1
]}

De Koker, Stefaan ^{[5
]}

De Geest, Bruno G. ^{[1
]}

机构：

[1] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium

[2] VIB Inflammat Res Ctr, B-9052 Zwijnaarde, Belgium

[3] Univ Ghent, Dept Resp Med, B-9000 Ghent, Belgium

[4] Univ Ghent, Dept Organ Chem, Supramol Chem Grp, B-9000 Ghent, Belgium

[5] Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde, Belgium

来源：

ADVANCED FUNCTIONAL MATERIALS | 2014年 / 24卷 / 29期

关键词：

microparticles; vaccines; dendritic cells; hydrogen bonding; self-assembly; DENDRITIC CELLS; POLYELECTROLYTE MICROCAPSULES; NANOPARTICLE VACCINES; MULTILAYER CAPSULES; SYNTHETIC VACCINES; DRUG-DELIVERY; IMMUNITY; ANTIGEN; POLYPHENOL; RESPONSES;

D O I：

10.1002/adfm.201400763

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Nanoporous microparticles are produced in a single step based on hydrogen bonding between a neutral polymer and tannic acid. These particles are stable in physiological medium, are non-toxic to in vitro cultured cells, and can efficiently encapsulate proteins. In vitro and in vivo experiments show that these porous hydrogen bonded microparticles are able to induce antigen-specific cellular and humoral immune responses against encapsulated vaccine antigens. Considering the easy and low cost manufacturing of this dry powder formulation from approved readily available components, it is anticipated that this technology holds great promise for the formulation of vaccines for developing countries or for pandemic vaccines where long term storage under refrigerated conditions is a major issue. Additionally, due to the versatility of the approach facilitates straightforward co-encapsulation of a wide variety of additional components to further modulate the immune response.

引用

页码：4634 / 4644

页数：11

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