Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

被引：154

作者：

De Koker, Stefaan ^{[2
]}

De Geest, Bruno G. ^{[1
]}

Singh, Satwinder K. ^{[4
]}

De Rycke, Riet ^{[2
,3
]}

Naessens, Thomas ^{[2
]}

Van Kooyk, Yvette ^{[4
]}

Demeester, Jo ^{[5
]}

De Smedt, Stefaan C. ^{[5
]}

Grooten, Johan ^{[2
]}

机构：

[1] Univ Ghent, Dept Pharmaceut, Pharmaceut Technol Lab, Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

[3] VIB, Dept Mol Biomed Res, Ghent, Belgium

[4] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands

[5] Univ Ghent, Dept Pharmaceut, Gen Biochem & Phys Pharm Labs, Ghent, Belgium

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 45期

关键词：

antigens capsules; dendritic cells; polyelectrolytes; MULTILAYER CAPSULES; MECHANISMS; PARTICLES; VACCINES; INTERNALIZATION; INHIBITION; ACTIVATION; SYSTEM;

D O I：

10.1002/anie.200903769

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stand and deliver: Degradable polyelectrolyte microcapsules (PMs; see picture) as antigen delivery vehicles are taken up by dendritic cells (DCs) by macropinocytosis. Following uptake, the shell of the microcapsules ruptures, resulting in the invasion of the capsules by the cellular cytoplasm, thus allowing DCs to efficiently process encapsulated antigen. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8485 / 8489

页数：5

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