Synthesis of novel and diverse mollugin analogues and their antibacterial and antioxidant activities

被引：28

作者：

Idhayadhulla, Akber ^{[1
]}

Xia, Likai ^{[1
]}

Lee, Yong Rok ^{[1
]}

Kim, Sung Hong ^{[2
]}

Wee, Young-Jung ^{[3
]}

Lee, Chong-Soon ^{[4
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 712749, South Korea

[2] Korea Basic Sci Inst, Daegu Ctr, Anal Res Div, Taegu 702701, South Korea

[3] Yeungnam Univ, Dept Food Sci & Technol, Gyongsan 712749, South Korea

[4] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, South Korea

来源：

BIOORGANIC CHEMISTRY | 2014年 / 52卷

基金：

新加坡国家研究基金会;

关键词：

Mollugin; 3,4-Dihydromollugin; Antioxidant activity; Antibacterial activity; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; RUBIA; ANTHRAQUINONES; CONSTITUENTS; NAPHTHOQUINONES; ROOTS;

D O I：

10.1016/j.bioorg.2013.11.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Novel and diverse mollugin analogues (1-12) were synthesized using PhB(OH)(2)/AcOH-mediated electrocyclization reaction as a key step. The newly synthesized compounds were screened for antioxidant and antibacterial activities. Compounds 1, 2, 5, 6, 8, and 10-12 showed high antioxidant activities in DPPH inhibition (IC50 = 0.52-1.11 mu M) compared with BHT (IC50 = 9.67 mu M). Compounds 3 exhibited potent antibacterial activity against Staphylococcus aureus (KCTC-1916) bacterial strain at 100 mu g/mL. Structures of newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR data and high-resolution mass spectrometry. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：77 / 82

页数：6

共 46 条

[1]

[Anonymous], 1992, PHARMACOPEIA PEOPLES, P179

[2]

CHAIN-BREAKING NAPHTHOLIC ANTIOXIDANTS - ANTIOXIDANT ACTIVITIES OF POLYALKYLBENZOCHROMANOL, POLYALKYLBENZOCHROMENOL, AND 2,3-DIHYDRO-5-HYDROXY-2,2,4-TRIMETHYLNAPHTHO[1,2-B]FURAN COMPARED TO AN ALPHA-TOCOPHEROL MODEL IN SODIUM DODECYL-SULFATE MICELLES [J].