Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates

被引：269

作者：

Canivet, Jerome

Yamaguchi, Junichiro

Ban, Ikuya

Itami, Kenichiro ^{[1
]}

机构：

[1] Nagoya Univ, Dept Chem, Grad Sch Sci, Nagoya, Aichi 4648602, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 08期

关键词：

C-H-BOND; DIRECT ORTHO-ARYLATION; MEDIATED DIRECT ARYLATION; PYRIDINE-N-OXIDES; GRIGNARD-REAGENTS; ROOM-TEMPERATURE; ORGANIC HALIDES; SELECTIVE ALKENYLATION; ACTIVATION; FUNCTIONALIZATION;

D O I：

10.1021/ol9001587

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ni-based catalytic systems for the arylation of heteroarenes with aryl halides and triflates have been established. Ni(OAc)(2)/bipy is a general catalyst for aryl bromides/iodides, and Ni(OAC)(2)/dppf is effective for aryl chlorides/triflates. Thiazole, benzothiazole, oxazole, benzoxazole, and benzimidazole are applicable as heteroarene coupling partners. A rapid synthesis of febuxostat, a drug for gout and hyperuricemia, is also demonstrated.

引用

页码：1733 / 1736

页数：4

共 99 条

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