Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters

被引：22

作者：

Hargrave, Jonathan D.

Herbert, Jennifer

Bish, Gerwyn

Frost, Christopher G.

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 17期

关键词：

D O I：

10.1039/b606977k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cationic rhodium complex [Rh(cod)(2)][BF4] effectively catalyses the 1,4-addition of organotrialkoxysilanes to alpha-substituted acrylic esters. The reactions are promoted by heating in an oil-bath or more conveniently in a microwave reactor allowing rapid access to a useful range of functionalised products including 2-alkyl succinates and alpha-amino acid derivatives.

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页码：3235 / 3241

页数：7

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