Atropisomeric myristinins:: Selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea

被引：80

作者：

Sawadjoon, S

Kittakoop, P

Kirtikara, K

Vichai, V

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] Natl Ctr Genet Engn & Biotechnol, NSTDA, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 16期

关键词：

D O I：

10.1021/jo020045d

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The first naturally occurring atropisomeric flavans, myristinins B (2), C (2a), E (4), and F (4a), together with their corresponding trans-isomers, myristinins A (1) and D (3), were isolated from the CH2Cl2 extract of Myristica cinnamomea fruits. Compounds 1, the mixture of 2 and 2a, and the mixture of 4 and 4a, exhibited antifungal activity against Candida albicans with IC50 values ranging from 5.9 to 8.8 mug/mL, and they selectively inhibited the enzyme cyclooxygenase-2 (COX-2).

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页码：5470 / 5475

页数：6

相关论文

共 20 条

[1]

AKIRA M, 1992, J PHARMACOL EXP THER, V263, P1302

[2]

A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata [J].

Boonphong, S ;

Kittakoop, P ;

Isaka, M ;

Palittapongarnpim, P ;

Jaturapat, A ;

Danwisetkanjana, K ;

Tanticharoen, M ;

Thebtaranonth, Y .

PLANTA MEDICA, 2001, 67 (03) :279-281

[3]

Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex [J].

Boonphong, S ;

Kittakoop, P ;

Isaka, M ;

Pittayakhajonwut, D ;

Tanticharoen, M ;

Thebtaranonth, Y .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (07) :965-967

[4]

NEOLIGNANS FROM VIROLA-CARINATA FRUIT [J].

CAVALCANTE, SH ;

YOSHIDA, M ;

GOTTLIEB, OR .

PHYTOCHEMISTRY, 1985, 24 (05) :1051-1055

[5]

Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica [J].

Chinworrungsee, M ;

Kittakoop, P ;

Isaka, M ;

Rungrod, A ;

Tanticharoen, M ;

Thebtaranonth, Y .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (15) :1965-1969

[6]

Antimicrobial agents from plants: antibacterial activity of plant volatile oils [J].

Dorman, HJD ;

Deans, SG .

JOURNAL OF APPLIED MICROBIOLOGY, 2000, 88 (02) :308-316

[7]

Gonzalez M. J., 1988, Fitoterapia, V59, P486

[8]

STUDIES ON MEDICINAL AND RELATED PLANTS OF SRI LANKA .8. HORSFIELDIN, A LIGNAN AND OTHER CONSTITUENTS FROM HORSFIELDIA-IRYAGHEDHI [J].

GUNATILAKA, AAL ;

DESILVA, AMYJ ;

SOTHEESWARAN, S ;

TILLEKERATNE, LMV .

PHYTOCHEMISTRY, 1982, 21 (11) :2719-2723

[9]

CHEMOPREVENTIVE ACTION OF MACE (MYRISTICA-FRAGRANS, HOUTT) ON METHYLCHOLANTHRENE-INDUCED CARCINOGENESIS IN THE UTERINE CERVIX IN MICE [J].

HUSSAIN, SP ;

RAO, AR .

CANCER LETTERS, 1991, 56 (03) :231-234

[10]

NUTMEG AS A NARCOTIC - CONTRIBUTION TO CHEMISTRY AND PHARMACOLOGY OF NUTMEG (MYRISTICA-FRAGRANS) [J].

KALBHEN, DA .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1971, 10 (06) :370-&