Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid β-Peptide Aggregation and Neurotoxicity

被引：104

作者：

Chen, Tingting ^{[2
,3
]}

Wang, Xiaoyong ^{[1
]}

He, Yafeng ^{[2
]}

Zhang, Changli ^{[2
]}

Wu, Ziyi ^{[2
]}

Liao, Kuo ^{[2
]}

Wang, Jianjun ^{[4
]}

Guo, Zijian ^{[2
]}

机构：

[1] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

[3] Nantong Univ, Sch Chem & Chem Engn, Nantong 226019, Peoples R China

[4] Wayne State Univ, Sch Med, Detroit, MI 48202 USA

来源：

INORGANIC CHEMISTRY | 2009年 / 48卷 / 13期

关键词：

MACROCYCLIC TETRA-AMINES; ALZHEIMER A-BETA; METAL-IONS; NEURODEGENERATIVE DISEASES; MOLECULAR-MECHANISMS; PARKINSONS-DISEASES; HYDROGEN-PEROXIDE; TRANSGENIC MICE; CLEAVAGE AGENTS; SENILE PLAQUES;

D O I：

10.1021/ic900025x

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Amyloid beta-peptide (A beta) aggregation is highly associated with Alzheimer's disease, which is facilitated by Zn2+ and Cu2+. Macrocyclic polyamine chelators cyclen and cyclam, can effectively protect A beta against precipitation induced by Cu2+ or Zn2+; the production of H2O2 mediated by Cu-A beta can also be inhibited by these chelators.

引用

页码：5801 / 5809

页数：9

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