Social memory is impaired in neonatally ibotenic acid lesioned rats

被引：26

作者：

Becker, A ^{[1
]}

Grecksch, G ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany

来源：

BEHAVIOURAL BRAIN RESEARCH | 2000年 / 109卷 / 01期

关键词：

schizophrenia; rat; postnatal hippocampal lesion; ibotenic acid; social memory;

D O I：

10.1016/S0166-4328(99)00163-1

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Postnatal lesion with ibotenic acid in the ventral hippocampus produces several behavioural effects that resemble the symptoms of schizophrenia. In the present study, we tested neonatally lesioned 1-year-old Sprague-Dawley rats for their social memory. It was found that social memory is worsened in lesioned rats. Subchronic treatment with haloperidol (0.025 mg/kg body weight) partly ameliorated this impairment. It was suggested that social memory might be a useful paradigm to test clinically used and potential antipsychotic drugs for their effects on learning and memory processes. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：137 / 140

页数：4

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