Antimalarial activity of ferrocenyl chalcones

被引：170

作者：

Wu, X

Wilairat, P

Go, ML

机构：

[1] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore

[2] Mahidol Univ, Dept Biochem, Bangkok 10400, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(02)00430-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50 of 4.5 and 5.1 muM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2299 / 2302

页数：4

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