PI-loting membrane traffic

被引：257

作者：

De Matteis, MA ^{[1
]}

Godi, A ^{[1
]}

机构：

[1] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, I-66030 Santa Maria Imbaro, Chieti, Italy

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1038/ncb0604-487

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular distributions of the individual PI species. Specific PIs control the correct timing and location of many trafficking events. Their ultimate mode of action is not always well defined, but it includes localized recruitment of transport machinery, allosteric regulation of PI-binding proteins and changes in the physical properties of the membrane.

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页码：487 / 492

页数：6

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