Solid lipid nanoparticles for parenteral drug delivery

被引：1101

作者：

Wissing, SA

Kayser, O

Müller, RH

机构：

[1] Free Univ Berlin, Dept Pharmaceut Biopharmaceut & Biotechnol, D-12169 Berlin, Germany

[2] Drug Delivery Serv GmbH, DDS, D-24119 Kronshagen, Germany

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2004年 / 56卷 / 09期

关键词：

SLN; solid lipid nanoparticles; NLC; LDC; toxicity; pharmacokinetics; degradation; parenterals;

D O I：

10.1016/j.addr.2003.12.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review describes the use of nanoparticles based on solid lipids for the parenteral application of drugs. Firstly, different types of nanoparticles based on solid lipids such as "solid lipid nanoparticles" (SLN), "nanostructured lipid carriers" (NLC) and "lipid drug conjugate" (LDC) nanoparticles are introduced and structural differences are pointed out. Different production methods including the suitability for large scale production are described. Stability issues and drug incorporation mechanisms into the particles are discussed. In the second part, the biological activity of parenterally applied SLN and biopharmaceutical aspects such as pharmacokinetic profiles as well as toxicity aspects are reviewed. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1257 / 1272

页数：16

共 119 条

[11] SOLID LIPOSPHERES OF DOXORUBICIN AND IDARUBICIN [J].