HIV-1 gp120 modulates hypothalamic cytokine mRNAs in vivo: Implications to cytokine feedback systems

被引:35
作者
Ilyin, SE [1 ]
PlataSalaman, CR [1 ]
机构
[1] UNIV DELAWARE, SCH LIFE & HLTH SCI, DIV MOL BIOL, NEWARK, DE 19716 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1006/bbrc.1997.6131
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
HIV-1-derived envelope glycoprotein 120 (gp120) may play an important role in HIV-1 neuropathology. Gp120 may act through mediators including proinflammatory cytokines. Here, we investigated the regulation of the IL-1 beta system [IL-1 beta, IL-1 receptor type I (IL-1RI), IL-1 receptor antagonist (IL-1Ra), IL-1 receptor accessory proteins (IL-1R AcP I and II)], TNF-alpha, TGF-alpha, and TGF-beta 1 mRNAs in the hypothalamus of Wistar rats in response to the chronic intracerebroventricular (ICV) microinfusion (via osmotic minipumps) of HIV-1 gp120 (100, 500, and 1000 ng/24 h for 72 h). Gp120 increased IL-1 beta, IL-1Ra, TNF-alpha, and TGF-beta 1 mRNAs. Gp120-induced cytokine mRNA profiles were highly intercorrelated in the same samples. Levels of IL-1RI, IL-1R AcP I and II, and TGF-alpha did not change significantly, and levels of GAPDH mRNA were constant. The data suggest potential cytokine-cytokine interactions with positive (IL-1 beta <-> TNF-alpha) and negative (IL-1Ra --> IL-1 beta; TGF-beta 1 --> IL-1 beta/TNF-alpha) feedback in gp120 action. A dysregulation of the balance between stimulatory and inhibitory cytokine mechanisms may participate in the initiation, propagation, and/or aggravation of HIV-1 neuropathology. (C) 1997 Academic Press.
引用
收藏
页码:514 / 518
页数:5
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