Listeria monocytogenes - from saprophyte to intracellular pathogen

被引：447

作者：

Freitag, Nancy E. ^{[1
]}

Port, Gary C. ^{[2
]}

Miner, Maurine D. ^{[3
]}

机构：

[1] Univ Illinois, Dept Microbiol & Immunol MC790, Chicago, IL 60612 USA

[2] Washington Univ, Dept Mol Microbiol, St Louis, MO 63110 USA

[3] Seattle Biomed Res Inst, Seattle, WA 98109 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 09期

基金：

美国国家科学基金会;

关键词：

VIRULENCE REGULATOR PRFA; PHOSPHOLIPASE-C ACTIVITY; TO-CELL SPREAD; TRANSCRIPTIONAL ACTIVATOR; IMMUNE-RESPONSES; IN-VITRO; CONSTITUTIVE ACTIVATION; BACTERIAL PATHOGENESIS; MUTATIONAL ACTIVATION; MOLECULAR ANALYSIS;

D O I：

10.1038/nrmicro2171

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. Recent studies suggest that L. monocytogenes mediates its saprophyte-to-cytosolic-parasite transition through the careful modulation of the activity of a virulence regulatory protein known as PrfA, using a range of environmental cues that include available carbon sources. In this Progress article we describe the regulation of PrfA and its role in the L. monocytogenes transition from the saprophytic stage to the virulent intracellular stage.

引用

页码：623 / 628

页数：6

共 81 条

[41] IDENTIFICATION OF PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C ACTIVITY IN LISTERIA-MONOCYTOGENES - A NOVEL TYPE OF VIRULENCE FACTOR [J].

MENGAUD, J ;

BRAUNBRETON, C ;

COSSART, P .

MOLECULAR MICROBIOLOGY, 1991, 5 (02) :367-372

[42] Carbon-source regulation of virulence gene expression in Listeria monocytogenes [J].

Milenbachs, AA ;

Brown, DP ;

Moors, M ;

Youngman, P .

MOLECULAR MICROBIOLOGY, 1997, 23 (05) :1075-1085

[43] Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA [J].

Milohanic, E ;

Glaser, P ;

Coppée, JY ;

Frangeul, L ;

Vega, Y ;

Vázquez-Boland, JA ;

Kunst, F ;

Cossart, P ;

Buchrieser, C .

MOLECULAR MICROBIOLOGY, 2003, 47 (06) :1613-1625

[44] A novel prfA mutation that promotes Listeria monocytogenes cytosol entry but reduces bacterial spread and cytotoxicity [J].

Miner, Maurine D. ;

Port, Gary C. ;

Bouwer, H. G. Archie ;

Chang, Jennifer C. ;

Freitag, Nancy E. .

MICROBIAL PATHOGENESIS, 2008, 45 (04) :273-281

[45] Functional impact of mutational activation on the Listeria monocytogenes central virulence regulator PrfA [J].

Miner, Maurine D. ;

Port, Gary C. ;

Freitag, Nancy E. .

MICROBIOLOGY-SGM, 2008, 154 :3579-3589

[46]

Monk IR, 2008, APPL ENVIRON MICROB, V74, P3921, DOI 10.1128/AEM.00314-08

[47] Pleiotropic enhancement of bacterial pathogenesis resulting from the constitutive activation of the Listeria monocytogenes regulatory factor PrfA [J].

Mueller, KJ ;

Freitag, NE .

INFECTION AND IMMUNITY, 2005, 73 (04) :1917-1926

[48] Listeria intracellular growth and virulence require host-derived lipoic acid [J].

O'Riordan, M ;

Moors, MA ;

Portnoy, DA .

SCIENCE, 2003, 302 (5644) :462-464

[49] σB- and PrfA-dependent transcription of genes previously classified as putative constituents of the Listeria monocytogenes PrfA regulon [J].

Ollinger, Juliane ;

Wiedmann, Martin ;

Boor, Kathryn J. .

FOODBORNE PATHOGENS AND DISEASE, 2008, 5 (03) :281-293

[50] Listeria monocytogenes σB Modulates PrfA-Mediated Virulence Factor Expression [J].

Ollinger, Juliane ;

Bowen, Barbara ;

Wiedmann, Martin ;

Boor, Kathryn J. ;

Bergholz, Teresa M. .

INFECTION AND IMMUNITY, 2009, 77 (05) :2113-2124

← 1 2 3 4 5 6 7 8 9 →