RNAi in moderation

被引：25

作者：

Barik, Sailen ^{[1
]}

机构：

[1] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL 36688 USA

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 07期

关键词：

D O I：

10.1038/nbt0706-796

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new animal study shows that too much RNAi is lethal.

引用

页码：796 / 797

页数：3

共 12 条

[1] Inhibition of respiratory viruses by nasally administered siRNA
Bitko, V
Musiyenko, A
Shulyayeva, O
Barik, S
[J]. NATURE MEDICINE, 2005, 11 (01) : 50 - 55
[2] Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses
Bitko V.
Barik S.
[J]. BMC Microbiology, 1 (1) : 1 - 11
[3] microPrimer: The biogenesis and function of microRNA
Du, TT
Zamore, PD
[J]. DEVELOPMENT, 2005, 132 (21): : 4645 - 4652
[4] Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Grimm, Dirk
Streetz, Konrad L.
Jopling, Catherine L.
Storm, Theresa A.
Pandey, Kusum
Davis, Corrine R.
Marion, Patricia
Salazar, Felix
Kay, Mark A.
[J]. NATURE, 2006, 441 (7092) : 537 - 541
[5] Sequence-specific inhibition of small RNA function
Hutvágner, G
Simard, MJ
Mello, CC
Zamore, PD
[J]. PLOS BIOLOGY, 2004, 2 (04) : 465 - 475
[6] Expression profiling reveals off-target gene regulation by RNAi
Jackson, AL
Bartz, SR
Schelter, J
Kobayashi, SV
Burchard, J
Mao, M
Li, B
Cavet, G
Linsley, PS
[J]. NATURE BIOTECHNOLOGY, 2003, 21 (06) : 635 - 637
[7] Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner
Lugli, G
Larson, J
Martone, ME
Jones, Y
Smalheiser, NR
[J]. JOURNAL OF NEUROCHEMISTRY, 2005, 94 (04) : 896 - 905
[8] Activation of the mammalian immune system by siRNAs
Marques, JT
Williams, BRG
[J]. NATURE BIOTECHNOLOGY, 2005, 23 (11) : 1399 - 1405
[9] Revealing the world of RNA interference
Mello, CC
Conte, D
[J]. NATURE, 2004, 431 (7006) : 338 - 342
[10] Second-generation shRNA libraries covering the mouse and human genomes
Silva, JM
Li, MZ
Chang, K
Ge, W
Golding, MC
Rickles, RJ
Siolas, D
Hu, G
Paddison, PJ
Schlabach, MR
Sheth, N
Bradshaw, J
Burchard, J
Kulkarni, A
Cavet, G
Sachidanandam, R
McCombie, WR
Cleary, MA
Elledge, SJ
Hannon, GJ
[J]. NATURE GENETICS, 2005, 37 (11) : 1281 - 1288

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