Microchip-based high-throughput screening analysis of combinatorial libraries

被引：62

作者：

Khandurina, J ^{[1
]}

Guttman, A ^{[1
]}

机构：

[1] Torrey Mesa Res Inst, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(02)00323-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, there have been significant advances in biochemical assay miniaturization and integration of microchip-based technologies with combinatorial library screening for high-throughput and large-scale applications. Small-molecule microarrays, protein arrays and cell-based arrays and conventional DNA arrays as well as microfluidic approaches in HTS are discussed in this review.

引用

收藏

页码：359 / 366

页数：8

相关论文

共 52 条

[1]

[Anonymous], ANAL CHEM

[2] Protein microchips: Use for immunoassay and enzymatic reactions [J].

Arenkov, P ;

Kukhtin, A ;

Gemmell, A ;

Voloshchuk, S ;

Chupeeva, V ;

Mirzabekov, A .

ANALYTICAL BIOCHEMISTRY, 2000, 278 (02) :123-131

[3] A chemical switch for inhibitor-sensitive alleles of any protein kinase [J].

Bishop, AC ;

Ubersax, JA ;

Petsch, DT ;

Matheos, DP ;

Gray, NS ;

Blethrow, J ;

Shimizu, E ;

Tsien, JZ ;

Schultz, PG ;

Rose, MD ;

Wood, JL ;

Morgan, DO ;

Shokat, KM .

NATURE, 2000, 407 (6802) :395-401

[4] Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale [J].

Borchardt, A ;

Liberles, SD ;

Biggar, SR ;

Crabtree, GR ;

Schreiber, SL .

CHEMISTRY & BIOLOGY, 1997, 4 (12) :961-968

[5] A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR) [J].

Chan, TF ;

Carvalho, J ;

Riles, L ;

Zheng, XFS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13227-13232

[6] A microfluidics platform for cell fusion - Commentary [J].

Chiu, DT .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2001, 5 (05) :609-612

[7] Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems [J].

Chiu, DT ;

Jeon, NL ;

Huang, S ;

Kane, RS ;

Wargo, CJ ;

Choi, IS ;

Ingber, DE ;

Whitesides, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2408-2413

[8] DNA chips: a new tool for genetic analysis and diagnostics [J].

Cuzin, M .

TRANSFUSION CLINIQUE ET BIOLOGIQUE, 2001, 8 (03) :291-296

[9]

DORMAN G, 2001, CURR DRUG DISC, P21

[10] Drug discovery: A historical perspective [J].

Drews, J .

SCIENCE, 2000, 287 (5460) :1960-1964

← 1 2 3 4 5 6 →