T2*-Weighted MRI versus Oxygen Extraction Fraction PET in Acute Stroke

被引：17

作者：

Donswijk, M. L. ^{[1
]}

Jones, P. S. ^{[1
]}

Guadagno, J. V. ^{[1
]}

Carpenter, T. A. ^{[2
]}

Moustafa, R. R. ^{[1
]}

Fryer, T. D. ^{[2
]}

Aigbirhio, F. I. ^{[2
]}

Warburton, E. A. ^{[3
]}

Baron, J. C. ^{[1
]}

机构：

[1] Univ Cambridge, Stroke Res Grp, Cambridge CB2 2QQ, England

[2] Univ Cambridge, Wolfson Brain Imaging Ctr, Dept Clin Neurosci, Cambridge CB2 2QQ, England

[3] Univ Cambridge, Dept Med, Stroke Unit, Cambridge CB2 2QQ, England

来源：

CEREBROVASCULAR DISEASES | 2009年 / 28卷 / 03期

基金：

英国医学研究理事会;

关键词：

Magnetic resonance imaging; Positron emission tomography; Cerebral ischemia; MAGNETIC-RESONANCE IMAGE; ACUTE ISCHEMIC-STROKE; CEREBRAL-ISCHEMIA; MISERY-PERFUSION; RELAXATION-TIME; FOCAL ISCHEMIA; GRADIENT-ECHO; RAT-BRAIN; DIFFUSION; TISSUE;

D O I：

10.1159/000229017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Mapping high oxygen extraction fraction (OEF) in acute stroke is of considerable interest to depict the at-risk tissue. Being sensitive to deoxyhemoglobin, T2*-weighted MRI has been suggested as a potential marker of high OEF. Methods: We compared T2*-weighted images from pre-contrast arrival perfusion scans against quantitative positron emission tomography in 5 patients studied 7-21 h after onset of carotid territory stroke. OEF and T2* signal were obtained in the voxels with significantly high OEF. Results: All patients showed increased OEF. No significant relationship between OEF and T2*-weighted signal was found either within or between subjects. Conclusion: We found no indication that T2*-weighted MRI in the way implemented in this investigation was sensitive to high OEF in acute stroke. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：306 / 313

页数：8

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