Thermosensitive PEGylated polypeptides

被引：18

作者：

Cho, JY

Sohn, YS

Gutowska, A

Jeong, B ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem, Div Nanosci, Seoul 120750, South Korea

[2] PNNL, Richland, WA 99352 USA

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2004年 / 25卷 / 09期

关键词：

biodegradable; drug delivery systems; nanoparticles; peptides; thermal properties;

D O I：

10.1002/marc.200300318

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents 0 C and undergoes a micelle (radius approximate to 10 nm) to nanoparticle (radius approximate to 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to E between 30 and 40degreesC by varying the number of poly(ethylene glycol) grafts. This system might be promising for advanced drug delivery.

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页码：964 / 967

页数：4

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