Altered structure of autoantigens during apoptosis

被引：61

作者：

Hall, JC

Casciola-Rosen, L

Rosen, A

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Cell Biol & Anat, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Div Rheumatol, Baltimore, MD 21205 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2004年 / 30卷 / 03期

关键词：

D O I：

10.1016/j.rdc.2004.04.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clustering and concentration of autoantigens at the surface of apoptotic cells, in combination with the striking tolerance-inducing function of apoptotic cells, have focused attention on abnormalities in apoptotic cell execution and clearance as potential susceptibility and initiating factors in systemic autoimmunity. Structural changes that occur during cell death may influence the immunogenicity of self antigens. This article discusses the modifications that autoantigens undergo during cell death, identifies certain proimmune forms of apoptotic death in which autoantigen structure is frequently modified, and reviews the mechanisms through which such structural changes might lead to initiation of an autoimmune response.

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页码：455 / +

页数：18

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