DNA-encoded chemical libraries

被引：47

作者：

Scheuermann, Joerg ^{[1
]}

Dumelin, Christoph E. ^{[1
]}

Melkko, Samu ^{[1
]}

Neri, Dario ^{[1
]}

机构：

[1] ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF BIOTECHNOLOGY | 2006年 / 126卷 / 04期

关键词：

drug discovery; chemical libraries; DNA-encoding; self-assembly; DNA-templated synthesis; affinity-based selections;

D O I：

10.1016/j.jbiotec.2006.05.018

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The discovery and development of novel drugs for the multitude of targets originating from functional genomic research is a challenging task. While antibodies can nowadays be raised against virtually any given target using phage-display methodologies, a similar "selection/amplification" approach for the facile discovery of low-molecular weight compounds capable of specific binding to protein targets of choice has so far been lacking. The development of DNA-encoded chemical libraries, combined with suitable selection and high-throughput sequencing strategies, holds promises to fill this gap. Here, we review the latest developments in the field of DNA-encoded chemical libraries, commenting on the challenges and opportunities for the different experimental strategies in this rapidly evolving research area, which may gain importance for the future drug discovery process. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：568 / 581

页数：14

共 64 条

[31] A NEW TYPE OF SYNTHETIC PEPTIDE LIBRARY FOR IDENTIFYING LIGAND-BINDING ACTIVITY [J].

LAM, KS ;

SALMON, SE ;

HERSH, EM ;

HRUBY, VJ ;

KAZMIERSKI, WM ;

KNAPP, RJ .

NATURE, 1991, 354 (6348) :82-84

[32] Initial sequencing and analysis of the human genome [J].

Lander, ES ;

Int Human Genome Sequencing Consortium ;

Linton, LM ;

Birren, B ;

Nusbaum, C ;

Zody, MC ;

Baldwin, J ;

Devon, K ;

Dewar, K ;

Doyle, M ;

FitzHugh, W ;

Funke, R ;

Gage, D ;

Harris, K ;

Heaford, A ;

Howland, J ;

Kann, L ;

Lehoczky, J ;

LeVine, R ;

McEwan, P ;

McKernan, K ;

Meldrim, J ;

Mesirov, JP ;

Miranda, C ;

Morris, W ;

Naylor, J ;

Raymond, C ;

Rosetti, M ;

Santos, R ;

Sheridan, A ;

Sougnez, C ;

Stange-Thomann, N ;

Stojanovic, N ;

Subramanian, A ;

Wyman, D ;

Rogers, J ;

Sulston, J ;

Ainscough, R ;

Beck, S ;

Bentley, D ;

Burton, J ;

Clee, C ;

Carter, N ;

Coulson, A ;

Deadman, R ;

Deloukas, P ;

Dunham, A ;

Dunham, I ;

Durbin, R ;

French, L .

NATURE, 2001, 409 (6822) :860-921

[33] DNA-Templated organic synthesis: Nature's strategy for controlling chemical reactivity applied to synthetic molecules [J].

Li, XY ;

Liu, DR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (37) :4848-4870

[34] Innovation - Target discovery [J].

Lindsay, MA .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (10) :831-838

[35] Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings (Reprinted from Advanced Drug Delivery Reviews, vol 23, pg 3-25, 1997) [J].

Lipinski, CA ;

Lombardo, F ;

Dominy, BW ;

Feeney, PJ .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 46 (1-3) :3-26

[36] A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries [J].

Liu, RW ;

Mark, J ;

Lam, KS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (26) :7678-7680

[37] DNA microarrays as decoding tools in combinatorial chemistry and chemical biology [J].

Lovrinovic, M ;

Niemeyer, CM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (21) :3179-3183

[38] Genome sequencing in microfabricated high-density picolitre reactors [J].

Margulies, M ;

Egholm, M ;

Altman, WE ;

Attiya, S ;

Bader, JS ;

Bemben, LA ;

Berka, J ;

Braverman, MS ;

Chen, YJ ;

Chen, ZT ;

Dewell, SB ;

Du, L ;

Fierro, JM ;

Gomes, XV ;

Godwin, BC ;

He, W ;

Helgesen, S ;

Ho, CH ;

Irzyk, GP ;

Jando, SC ;

Alenquer, MLI ;

Jarvie, TP ;

Jirage, KB ;

Kim, JB ;

Knight, JR ;

Lanza, JR ;

Leamon, JH ;

Lefkowitz, SM ;

Lei, M ;

Li, J ;

Lohman, KL ;

Lu, H ;

Makhijani, VB ;

McDade, KE ;

McKenna, MP ;

Myers, EW ;

Nickerson, E ;

Nobile, JR ;

Plant, R ;

Puc, BP ;

Ronan, MT ;

Roth, GT ;

Sarkis, GJ ;

Simons, JF ;

Simpson, JW ;

Srinivasan, M ;

Tartaro, KR ;

Tomasz, A ;

Vogt, KA ;

Volkmer, GA .

NATURE, 2005, 437 (7057) :376-380

[39] Encoded self-assembling chemical libraries [J].

Melkko, S ;

Scheuermann, J ;

Dumelin, CE ;

Neri, D .

NATURE BIOTECHNOLOGY, 2004, 22 (05) :568-574

[40] On the magnitude of the chelate effect for the recognition of proteins by pharmacophores scaffolded by self-assembling oligonucleotides [J].

Melkko, S ;

Dumelin, CE ;

Scheuermann, J ;

Neri, D .

CHEMISTRY & BIOLOGY, 2006, 13 (02) :225-231

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