Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix

被引:153
作者
Buccione, Roberto [1 ]
Caldieri, Giusi [1 ]
Ayala, Inmaculada [1 ]
机构
[1] Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, Tumor Cell Invas Lab, I-66030 Chieti, Italy
关键词
Invadopodia; Cell adhesion; Cell invasion; Extracellular matrix degradation; NUCLEOTIDE EXCHANGE FACTORS; PERICELLULAR PROTEOLYSIS; BREAST-CANCER; TYROSINE PHOSPHORYLATION; PODOSOME FORMATION; ACTIN DYNAMICS; RHO-GTPASES; CYCLIN D1; PLASMINOGEN-ACTIVATOR; MEMBRANE DYNAMICS;
D O I
10.1007/s10555-008-9176-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Invasive tumor-derived or transformed cells, cultured on a flat extracellular matrix substratum, extend specialized proteolytically active plasma membrane protrusions. These structures, termed invadopodia, are responsible for the focal degradation of the underlying substrate. Considerable progress has been made in recent years towards understanding the basic molecular components and regulatory circuits and the ultrastructural features of invadopodia. This has generated substantial interest in invadopodia as a paradigm to study the complex interactions between the intracellular trafficking, signal transduction and cytoskeleton regulation machineries; hopes are high that they may also represent valid biological targets to help advance the anti-cancer drug discovery process. Current knowledge will be reviewed here with an emphasis on the many open questions in invadopodia biology.
引用
收藏
页码:137 / 149
页数:13
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