Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery

被引：235

作者：

Tang, Ling-Yan ^{[1
,2
]}

Wang, Yu-Cai ^{[3
]}

Li, Yang ^{[1
,2
]}

Du, Jin-Zhi ^{[3
]}

Wang, Jun ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[3] Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China

来源：

BIOCONJUGATE CHEMISTRY | 2009年 / 20卷 / 06期

基金：

中国国家自然科学基金;

关键词：

CONTROLLED-RELEASE; GENE DELIVERY; PH; GLUTATHIONE; CANCER; POLY(EPSILON-CAPROLACTONE); NANOCARRIERS; ASSEMBLIES; NANOGELS; POLYMER;

D O I：

10.1021/bc900144m

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Aiming at development of a micellar nanoparticle system for intracellular drug release triggered by glutathione in tumor cells, a disulfide-linked biodegradable diblock copolymer of poly(E-caprolactone) and poly(ethyl ethylene phosphate) was synthesized. It formed biocompatible micelles loaded with doxorubicin in aqueous solution but detached the shell material under glutathione stimulus, resulting in rapid drug release with destruction of micellar structure. These glutathione-sensitive micelles also rapidly released the drug molecules intracellularly and led to enhanced growth inhibition to A549 tumor cells, suggesting that this nanoparticle system may have potential for improving drug delivery efficacy.

引用

页码：1095 / 1099

页数：5

共 27 条

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[2]

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