α/β hydrolase fold enzymes:: the family keeps growing

被引:716
作者
Nardini, M
Dijkstra, BW
机构
[1] Univ Groningen, Biophys Chem Lab, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, BIOSON Res Inst, NL-9747 AG Groningen, Netherlands
关键词
D O I
10.1016/S0959-440X(99)00037-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The alpha/beta hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a common ancestor. Recently solved structures demonstrate a considerably increased variability in fold architecture and substrate specificity, necessitating the redefinition of the minimal features that distinguish the family.
引用
收藏
页码:732 / 737
页数:6
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