DNA sequence from the unzipping force? One mutation problem

被引:16
作者
Bhattacharjee, SM [1 ]
Marenduzzo, D
机构
[1] Inst Phys, Bhubaneswar 751005, Orissa, India
[2] SISSA, Int Sch Adv Studies, I-34014 Trieste, Italy
[3] INFM, I-34014 Trieste, Italy
来源
JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL | 2002年 / 35卷 / 26期
关键词
D O I
10.1088/0305-4470/35/26/101
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
The possibility of detecting mutations in DNA from force measurements (as a first step towards sequence analysis) is discussed theoretically based on exact calculations. The force signal is associated with the domain wall separating the zipped from the unzipped regions. We propose a comparison method (`differential force microscope') to detect mutations. Two lattice models are treated as specific examples.
引用
收藏
页码:L349 / L356
页数:8
相关论文
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