Inhibition of naringinase (L-rhamnosidase) by piperidine analogues of L-rhamnose: Scaffolds for libraries incorporating trihydroxypipecolic acids

被引：39

作者：

Shilvock, JP

Wheatley, JR

Davis, B

Nash, RJ

Griffiths, RC

Jones, MG

Muller, M

Crook, S

Watkin, DJ

Smith, C

Besra, GS

Brennan, PJ

Fleet, GWJ

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] INST GRASSLAND & ENVIRONM RES,ABERYSTWYTH SY23 3EB,CARDIGANSHIRE,WALES

[3] UNIV WALES,INST BIOL SCI,ABERYSTWYTH SY23 1DB,DYFED,WALES

[4] CHEM CRYSTALLOG LAB,OXFORD OX1 3QU,ENGLAND

[5] GLAXO WELLCOME RES & DEV LTD,MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

[6] COLORADO STATE UNIV,DEPT MICROBIOL,FT COLLINS,CO 80523

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 47期

关键词：

D O I：

10.1016/0040-4039(96)01958-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

L-Deoxyrhamnojirimycin 1 does not inhibit naringinase significantly but 5-epi-L-deoxyrhamnojirimycin 2 is a potent inhibitor. Conversely, alpha-C-glycosides of 1 are good inhibitors of L-rhamnosidase whereas those of 2 are not. Intermediate azabicyclic lactones are Likely to be of use for the: incorporation of a number of trihydroxypipecolic acids into peptide libraries. Copyright (C) 1996 Elsevier Science Ltd

引用

收藏

页码：8569 / 8572

页数：4

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