The effect of polyamidoamine dendrimers on human erythrocyte membrane acetylcholine sterase activity

被引：51

作者：

Klajnert, B ^{[1
]}

Sadowska, M ^{[1
]}

Bryszewska, M ^{[1
]}

机构：

[1] Univ Lodz, Dept Gen Biophys, PL-90237 Lodz, Poland

来源：

BIOELECTROCHEMISTRY | 2004年 / 65卷 / 01期

关键词：

acetylcholinesterase; erythrocyte membrane; erythrocyte ghosts; Michaelis-Menten constant; dendrimer;

D O I：

10.1016/j.bioelechem.2004.06.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyamidoamine (PAMAM) dendrimers impact on activity of acetylcholinesterase was studied. It has been shown that denchimers induce a biphasic effect: depending on their concentrations they increase or decrease enzyme activity. It may be due to two types of interactions: direct-between dendrimers and the enzyme; indirect-via a modification of the physical state of membrane phospholipids affecting the acetylcholinesterase. (C) 2004 Elsevier B.V. All rights reserved.

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页码：23 / 26

页数：4

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