Opinion - Integrated global profiling of cancer

被引：98

作者：

Hanash, S ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 08期

关键词：

D O I：

10.1038/nrc1414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumours are complex biological systems. No single type of molecular approach fully elucidates tumour behaviour, necessitating analysis at multiple levels encompassing genomics and proteomics. Integrated data sets are required to fully determine the contributions of genome alterations, host factors and environmental exposures to tumour growth and progression, as well as the consequences of interactions between malignant or premalignant cells and their microenvironment. The sheer amount and heterogeneous nature of data that need to be collected and integrated are daunting, but effort has already begun to address these obstacles.

引用

页码：638 / 644

页数：7

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