Roles of peroxisome proliferator-activated receptor δ in skeletal muscle function and adaptation

被引:18
作者
Fredenrich, A [1 ]
Grimaldi, PA [1 ]
机构
[1] Univ Nice, Ctr Biochim, INSERM, U636, F-06108 Nice, France
关键词
insulin resistance; lipid disorder; lipid metabolism; type; 2; diabetes;
D O I
10.1097/01.mco.0000134370.93686.0a
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of the review Peroxisome proliferator-activated receptors mediate the transcriptional effects of fatty acids and fatty acid metabolites and regulate many physiological functions including development and metabolism. The roles of peroxisome proliferator-activated receptor alpha and gamma isotypes have been well established, while the functions of the third member of the family, peroxisome proliferator-activated receptor delta, remained unclear until very recently. This review focuses on the physiological functions of the nuclear receptor and especially on its roles in the control of fatty acid metabolism. Recent findings We review very recent data demonstrating that peroxisome proliferator-activated receptor delta plays a central role in the regulation of fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue, and also that the nuclear receptor is involved in cholesterol metabolism. Summary Use of potent and specific peroxisome proliferator-activated receptor delta agonists and appropriate transgenic animal models revealed the importance of this nuclear receptor in regulation of fatty acid catabolism in skeletal muscle and other tissues. It also indicated the potential of peroxisome proliferator-activated receptor delta as a therapeutic target in pathologies such as metabolic syndrome. However, the effects of peroxisome proliferator-activated receptor delta activation in atherosclerosis and the control of cell proliferation remain to be established.
引用
收藏
页码:377 / 381
页数:5
相关论文
共 29 条
[1]   The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones [J].
Arner, P .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2003, 14 (03) :137-145
[2]   PPARγ is a very low-density lipoprotein sensor in macrophages [J].
Chawla, A ;
Lee, CH ;
Barak, Y ;
He, WM ;
Rosenfeld, J ;
Liao, D ;
Han, J ;
Kang, H ;
Evans, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :1268-1273
[3]   The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells [J].
Dressel, U ;
Allen, TL ;
Pippal, JB ;
Rohde, PR ;
Lau, P ;
Muscat, GEO .
MOLECULAR ENDOCRINOLOGY, 2003, 17 (12) :2477-2493
[4]   Peroxisome proliferator-activated receptor (PPAR) α and PPARβ/δ, but not PPARγ, modulate the expression of genes involved in cardiac lipid metabolism [J].
Gilde, AJ ;
van der Lee, KAJM ;
Willemsen, PHM ;
Chinetti, G ;
van der Leij, FR ;
van der Vusse, GJ ;
Staels, B ;
van Bilsen, M .
CIRCULATION RESEARCH, 2003, 92 (05) :518-524
[5]   PPARδ activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells [J].
Glinghammar, B ;
Skogsberg, J ;
Hamsten, A ;
Ehrenborg, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 308 (02) :361-368
[6]   Roles of peroxisome proliferator-activated receptors delta and gamma in myoblast transdifferentiation [J].
Holst, D ;
Luquet, S ;
Kristiansen, K ;
Grimaldi, PA .
EXPERIMENTAL CELL RESEARCH, 2003, 288 (01) :168-176
[7]   Nutritional regulation and role of peroxisome proliferator-activated receptor δ in fatty acid catabolism in skeletal muscle [J].
Holst, D ;
Luquet, S ;
Nogueira, V ;
Kristiansen, K ;
Leverve, X ;
Grimaldi, PA .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2003, 1633 (01) :43-50
[8]   New factors in the regulation of adipose differentiation and metabolism [J].
Holst, D ;
Grimaldi, PA .
CURRENT OPINION IN LIPIDOLOGY, 2002, 13 (03) :241-245
[9]   The central role of fat and effect of peroxisome proliferatorm-activated receptor-γ on progression of insulin resistance and cardiovascular disease [J].
Hsueh, WA ;
Law, R .
AMERICAN JOURNAL OF CARDIOLOGY, 2003, 92 (4A) :3J-9J
[10]   Molecular mechanism of insulin resistance and obesity [J].
Kadowaki, T ;
Hara, K ;
Yamauchi, T ;
Terauchi, Y ;
Tobe, K ;
Nagai, R .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2003, 228 (10) :1111-1117